Somatomedin-like activity and muscle hypertrophy

Michael Sturek, D. R. Lamb, A. C. Snyder

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To study the association between somatomedin-like activity (SMLA) and overload-induced increases in muscle weight, SMLA in soleus muscles and blood plasma was determined in hypophysectomized rats following tenotomy of the gastrocnemius. The incorporation of 3H-thymidine into chick embryo fibroblasts was used to estimate SMLA. In 10 rats baseline values for SMLA were determined without tenotomy; in 19 rats SMLA was determined 3 days following tenotomy. Soleus muscles from tenotomized limbs were 24% heavier (p <.001) than contralateral controls. The SMLA in soleus muscles from tenotomized limbs was 50% greater (p <.01) than SMLA in contralateral control limbs. Similarly, plasma SMLA from the tenotomized group was 77% greater (p <.05) than plasma SMLA in the baseline group. In 22 of 26 cases where data for both left and right soleus muscle were obtained, the heavier muscle had greater SMLA. It is concluded that there is a substantial association between SMLA and overload-induced muscular hypertrophy.

Original languageEnglish (US)
Pages (from-to)760
Number of pages1
JournalIRCS Medical Science
Volume9
Issue number9
StatePublished - 1981
Externally publishedYes

Fingerprint

Somatomedins
Hypertrophy
Muscle
Muscles
Tenotomy
Skeletal Muscle
Rats
Extremities
Plasmas
Chick Embryo
Fibroblasts
Thymidine
Blood
Weights and Measures

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sturek, M., Lamb, D. R., & Snyder, A. C. (1981). Somatomedin-like activity and muscle hypertrophy. IRCS Medical Science, 9(9), 760.

Somatomedin-like activity and muscle hypertrophy. / Sturek, Michael; Lamb, D. R.; Snyder, A. C.

In: IRCS Medical Science, Vol. 9, No. 9, 1981, p. 760.

Research output: Contribution to journalArticle

Sturek, M, Lamb, DR & Snyder, AC 1981, 'Somatomedin-like activity and muscle hypertrophy', IRCS Medical Science, vol. 9, no. 9, pp. 760.
Sturek, Michael ; Lamb, D. R. ; Snyder, A. C. / Somatomedin-like activity and muscle hypertrophy. In: IRCS Medical Science. 1981 ; Vol. 9, No. 9. pp. 760.
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