Somatostatin analogue (octreotide) inhibits bile duct epithelial cell proliferation and fibrosis after extrahepatic biliary obstruction

T. F. Tracy, A. J. Tector, M. E. Goerke, S. Kitchen, D. Lagunoff

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Extrahepatic biliary obstruction leads to bile duct epithelial cell proliferation. Somatostatin and its analogue, octreotide, have been shown to inhibit DNA synthesis and proliferation in hepatocytes. We investigated the effect of octreotide on the biliary epithelial cell proliferative responses to biliary obstruction. Male Sprague-Dawley rats underwent common bile duct ligation and subcutaneous injection of either saline or octreotide (6 μg/kg) twice daily for 7 days. Morphometric analysis of hepatocytes, bile duct epithelial cells, and periportal connective tissue was performed by computerized point counting. Hepatocyte volume was preserved with octreotide treatment, which also significantly decreased bile duct proliferation and periportal extracellular matrix deposition in response to biliary obstruction compared with saline treated, duct-ligated animals. These results indicate that octreotide prevents the morphological changes that accompany extrahepatic biliary obstruction.

Original languageEnglish (US)
Pages (from-to)1574-1578
Number of pages5
JournalAmerican Journal of Pathology
Volume143
Issue number6
StatePublished - Dec 1 1993

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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