Somatostatin receptor subtypes in hormone-refractory (castration-resistant) prostatic carcinoma

Roberta Mazzucchelli, Doriana Morichetti, Marina Scarpelli, Aldo V. Bono, Antonio Lopez-Beltran, Liang Cheng, Ziya Kirkali, Rodolfo Montironi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The aim of this study was to examine the tissue expression and localisation of the somatostatin receptors (SSTRs) in hormone-refractory (HR) prostate cancer (PCa). Five SSTRs were evaluated immunohistochemically in 20 radical prostatectomies (RPs) with Gleason score (GS) 336 PCa, in 20 RPs with GS 448 and 459 PCa, and 20 transurethral resection of the prostate specimens with HR PCa. The mean values in the cytoplasm (all five SSTRs were expressed), membrane (only SSTR3 and SSTR4 were expressed) and nuclei (only SSTR4 and SSTR5 were expressed) of the glands in HR PCa were 20-70% lower than in the other two groups, the differences being statistically significant. All five SSTRs were expressed in the smooth muscle and endothelial cells of HR PCa, the mean values being lower than in the other two groups. In conclusion, this study expands our knowledge on the expression and localisation of five SSTRs in the various tissue components in the HR PCa compared with hormone-sensitive PCa.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalAsian Journal of Andrology
Volume13
Issue number2
DOIs
StatePublished - Mar 1 2011

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Keywords

  • hormone-refractory prostate cancer
  • prostate cancer progression
  • prostatic adenocarcinoma
  • somatostatin receptors

ASJC Scopus subject areas

  • Urology

Cite this

Mazzucchelli, R., Morichetti, D., Scarpelli, M., Bono, A. V., Lopez-Beltran, A., Cheng, L., Kirkali, Z., & Montironi, R. (2011). Somatostatin receptor subtypes in hormone-refractory (castration-resistant) prostatic carcinoma. Asian Journal of Andrology, 13(2), 242-247. https://doi.org/10.1038/aja.2010.100