Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound

Rong Yang, Kenyon K. Kopecky, Frederick J. Rescorla, Carlos A. Galliani, Eugene X. Wu, Jay L. Grosfeld

Research output: Contribution to journalArticle

45 Scopus citations


RATIONALE AND OBJECTIVES. The authors have previously demonstrated the ability of high-intensity focused ultrasound (HIFU) to extracorporeally induce selective tissue destruction in the liver without causing damage to the intervening abdominal wall. The potential usefulness of HIFU as a noninvasive therapy for liver cancer has been suggested. This study observes sonographic and computed tomography (CT) characteristics of HIFU-ablated liver tissue in an attempt to assess the possibility of using these imaging methods to monitor the therapeutic results. METHODS. A sonoablated lesion was induced in the liver in each of 20 rabbits with a HIFU therapeutic system. Sequential imaging of the hepatic sonolesions with sonography and CT was performed up to 8 days after treatment, and the imaging patterns were correlated with the histopathology. RESULTS. Hepatic sonoablated tissue could be clearly visualized by sonography as a hypoechoic lesion. On contrastenhanced CT, the sonolesions were depicted as nonenhanced low-density regions. There was good correlation among the sizes of sonography- and CT-depicted lesions and pathologic specimens. CONCLUSION. In this model, sonography and contrast-enhanced CT were useful imaging modalities for monitoring sonolesion evolution after HIFU treatment.

Original languageEnglish (US)
Pages (from-to)796-801
Number of pages6
JournalInvestigative Radiology
Issue number9
StatePublished - Sep 1993
Externally publishedYes


  • Computed tomography
  • Liver
  • Ultrasonography
  • Ultrasound therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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