Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound

Rong Yang, Kenyon K. Kopecky, Frederick Rescorla, Carlos A. Galliani, Eugene X. Wu, Jay L. Grosfeld

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

RATIONALE AND OBJECTIVES. The authors have previously demonstrated the ability of high-intensity focused ultrasound (HIFU) to extracorporeally induce selective tissue destruction in the liver without causing damage to the intervening abdominal wall. The potential usefulness of HIFU as a noninvasive therapy for liver cancer has been suggested. This study observes sonographic and computed tomography (CT) characteristics of HIFU-ablated liver tissue in an attempt to assess the possibility of using these imaging methods to monitor the therapeutic results. METHODS. A sonoablated lesion was induced in the liver in each of 20 rabbits with a HIFU therapeutic system. Sequential imaging of the hepatic sonolesions with sonography and CT was performed up to 8 days after treatment, and the imaging patterns were correlated with the histopathology. RESULTS. Hepatic sonoablated tissue could be clearly visualized by sonography as a hypoechoic lesion. On contrastenhanced CT, the sonolesions were depicted as nonenhanced low-density regions. There was good correlation among the sizes of sonography- and CT-depicted lesions and pathologic specimens. CONCLUSION. In this model, sonography and contrast-enhanced CT were useful imaging modalities for monitoring sonolesion evolution after HIFU treatment.

Original languageEnglish
Pages (from-to)796-801
Number of pages6
JournalInvestigative Radiology
Volume28
Issue number9
StatePublished - 1993
Externally publishedYes

Fingerprint

Tomography
Ultrasonography
Liver
Abdominal Wall
Liver Neoplasms
Therapeutics
Rabbits

Keywords

  • Computed tomography
  • Liver
  • Ultrasonography
  • Ultrasound therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound. / Yang, Rong; Kopecky, Kenyon K.; Rescorla, Frederick; Galliani, Carlos A.; Wu, Eugene X.; Grosfeld, Jay L.

In: Investigative Radiology, Vol. 28, No. 9, 1993, p. 796-801.

Research output: Contribution to journalArticle

Yang, Rong ; Kopecky, Kenyon K. ; Rescorla, Frederick ; Galliani, Carlos A. ; Wu, Eugene X. ; Grosfeld, Jay L. / Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound. In: Investigative Radiology. 1993 ; Vol. 28, No. 9. pp. 796-801.
@article{e4e72f3b19ec463697446b30ec3f20ec,
title = "Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound",
abstract = "RATIONALE AND OBJECTIVES. The authors have previously demonstrated the ability of high-intensity focused ultrasound (HIFU) to extracorporeally induce selective tissue destruction in the liver without causing damage to the intervening abdominal wall. The potential usefulness of HIFU as a noninvasive therapy for liver cancer has been suggested. This study observes sonographic and computed tomography (CT) characteristics of HIFU-ablated liver tissue in an attempt to assess the possibility of using these imaging methods to monitor the therapeutic results. METHODS. A sonoablated lesion was induced in the liver in each of 20 rabbits with a HIFU therapeutic system. Sequential imaging of the hepatic sonolesions with sonography and CT was performed up to 8 days after treatment, and the imaging patterns were correlated with the histopathology. RESULTS. Hepatic sonoablated tissue could be clearly visualized by sonography as a hypoechoic lesion. On contrastenhanced CT, the sonolesions were depicted as nonenhanced low-density regions. There was good correlation among the sizes of sonography- and CT-depicted lesions and pathologic specimens. CONCLUSION. In this model, sonography and contrast-enhanced CT were useful imaging modalities for monitoring sonolesion evolution after HIFU treatment.",
keywords = "Computed tomography, Liver, Ultrasonography, Ultrasound therapy",
author = "Rong Yang and Kopecky, {Kenyon K.} and Frederick Rescorla and Galliani, {Carlos A.} and Wu, {Eugene X.} and Grosfeld, {Jay L.}",
year = "1993",
language = "English",
volume = "28",
pages = "796--801",
journal = "Investigative Radiology",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Sonographic and computed tomography characteristics of liver ablation lesions induced by high-intensity focussed ultrasound

AU - Yang, Rong

AU - Kopecky, Kenyon K.

AU - Rescorla, Frederick

AU - Galliani, Carlos A.

AU - Wu, Eugene X.

AU - Grosfeld, Jay L.

PY - 1993

Y1 - 1993

N2 - RATIONALE AND OBJECTIVES. The authors have previously demonstrated the ability of high-intensity focused ultrasound (HIFU) to extracorporeally induce selective tissue destruction in the liver without causing damage to the intervening abdominal wall. The potential usefulness of HIFU as a noninvasive therapy for liver cancer has been suggested. This study observes sonographic and computed tomography (CT) characteristics of HIFU-ablated liver tissue in an attempt to assess the possibility of using these imaging methods to monitor the therapeutic results. METHODS. A sonoablated lesion was induced in the liver in each of 20 rabbits with a HIFU therapeutic system. Sequential imaging of the hepatic sonolesions with sonography and CT was performed up to 8 days after treatment, and the imaging patterns were correlated with the histopathology. RESULTS. Hepatic sonoablated tissue could be clearly visualized by sonography as a hypoechoic lesion. On contrastenhanced CT, the sonolesions were depicted as nonenhanced low-density regions. There was good correlation among the sizes of sonography- and CT-depicted lesions and pathologic specimens. CONCLUSION. In this model, sonography and contrast-enhanced CT were useful imaging modalities for monitoring sonolesion evolution after HIFU treatment.

AB - RATIONALE AND OBJECTIVES. The authors have previously demonstrated the ability of high-intensity focused ultrasound (HIFU) to extracorporeally induce selective tissue destruction in the liver without causing damage to the intervening abdominal wall. The potential usefulness of HIFU as a noninvasive therapy for liver cancer has been suggested. This study observes sonographic and computed tomography (CT) characteristics of HIFU-ablated liver tissue in an attempt to assess the possibility of using these imaging methods to monitor the therapeutic results. METHODS. A sonoablated lesion was induced in the liver in each of 20 rabbits with a HIFU therapeutic system. Sequential imaging of the hepatic sonolesions with sonography and CT was performed up to 8 days after treatment, and the imaging patterns were correlated with the histopathology. RESULTS. Hepatic sonoablated tissue could be clearly visualized by sonography as a hypoechoic lesion. On contrastenhanced CT, the sonolesions were depicted as nonenhanced low-density regions. There was good correlation among the sizes of sonography- and CT-depicted lesions and pathologic specimens. CONCLUSION. In this model, sonography and contrast-enhanced CT were useful imaging modalities for monitoring sonolesion evolution after HIFU treatment.

KW - Computed tomography

KW - Liver

KW - Ultrasonography

KW - Ultrasound therapy

UR - http://www.scopus.com/inward/record.url?scp=0027872370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027872370&partnerID=8YFLogxK

M3 - Article

C2 - 8225883

AN - SCOPUS:0027872370

VL - 28

SP - 796

EP - 801

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 9

ER -