Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: Incidence and time course

Nilo A. Avila, Thomas H. Shawker, Paris Roach, Mary H. Bradford, Monica C. Skarulis, Richard Eastman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose. We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. Methods. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Results. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. Conclusions. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalJournal of Clinical Ultrasound
Volume26
Issue number6
DOIs
StatePublished - Jul 1998
Externally publishedYes

Fingerprint

Ursodeoxycholic Acid
Acromegaly
Octreotide
abnormalities
Gallbladder
therapy
Ultrasonography
incidence
Incidence
Therapeutics
calculi
sludge
Calculi
Subcutaneous Injections
Sewage
Somatostatin
analogs
injection
intervals

Keywords

  • Acromegaly
  • Gallbladder
  • Octreotide
  • Ultrasonography
  • Ursodiol

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy : Incidence and time course. / Avila, Nilo A.; Shawker, Thomas H.; Roach, Paris; Bradford, Mary H.; Skarulis, Monica C.; Eastman, Richard.

In: Journal of Clinical Ultrasound, Vol. 26, No. 6, 07.1998, p. 289-294.

Research output: Contribution to journalArticle

Avila, Nilo A. ; Shawker, Thomas H. ; Roach, Paris ; Bradford, Mary H. ; Skarulis, Monica C. ; Eastman, Richard. / Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy : Incidence and time course. In: Journal of Clinical Ultrasound. 1998 ; Vol. 26, No. 6. pp. 289-294.
@article{9bc9ea29d8be446391bd75f3ed4c6bb0,
title = "Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: Incidence and time course",
abstract = "Purpose. We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. Methods. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Results. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72{\%} (13/18) and calculi in 39{\%} (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. Conclusions. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.",
keywords = "Acromegaly, Gallbladder, Octreotide, Ultrasonography, Ursodiol",
author = "Avila, {Nilo A.} and Shawker, {Thomas H.} and Paris Roach and Bradford, {Mary H.} and Skarulis, {Monica C.} and Richard Eastman",
year = "1998",
month = "7",
doi = "10.1002/(SICI)1097-0096(199807/08)26:6<289::AID-JCU2>3.0.CO;2-E",
language = "English (US)",
volume = "26",
pages = "289--294",
journal = "Journal of Clinical Ultrasound",
issn = "0091-2751",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy

T2 - Incidence and time course

AU - Avila, Nilo A.

AU - Shawker, Thomas H.

AU - Roach, Paris

AU - Bradford, Mary H.

AU - Skarulis, Monica C.

AU - Eastman, Richard

PY - 1998/7

Y1 - 1998/7

N2 - Purpose. We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. Methods. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Results. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. Conclusions. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.

AB - Purpose. We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. Methods. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Results. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. Conclusions. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.

KW - Acromegaly

KW - Gallbladder

KW - Octreotide

KW - Ultrasonography

KW - Ursodiol

UR - http://www.scopus.com/inward/record.url?scp=0031776038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031776038&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1097-0096(199807/08)26:6<289::AID-JCU2>3.0.CO;2-E

DO - 10.1002/(SICI)1097-0096(199807/08)26:6<289::AID-JCU2>3.0.CO;2-E

M3 - Article

C2 - 9641388

AN - SCOPUS:0031776038

VL - 26

SP - 289

EP - 294

JO - Journal of Clinical Ultrasound

JF - Journal of Clinical Ultrasound

SN - 0091-2751

IS - 6

ER -