Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: Incidence and time course

Nilo A. Avila, Thomas H. Shawker, Paris Roach, Mary H. Bradford, Monica C. Skarulis, Richard Eastman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Purpose. We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. Methods. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Results. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. Conclusions. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalJournal of Clinical Ultrasound
Volume26
Issue number6
DOIs
StatePublished - Jul 1 1998
Externally publishedYes

Keywords

  • Acromegaly
  • Gallbladder
  • Octreotide
  • Ultrasonography
  • Ursodiol

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Sonography of gallbladder abnormalities in acromegaly patients following octreotide and ursodiol therapy: Incidence and time course'. Together they form a unique fingerprint.

  • Cite this