Purpose. We studied the effects of octreotide and ursodiol on the gallbladders of patients with acromegaly. Methods. We performed gallbladder sonography in patients with acromegaly at various intervals during treatment. Group I (18 patients) was treated with subcutaneous injections of the somatostatin analogue octreotide. Group II (10 patients) was treated with ursodiol while receiving octreotide therapy. Results. Seventy-eight percent of patients receiving octreotide developed gallbladder abnormalities: sludge in 72% (13/18) and calculi in 39% (7/18). Ursodiol reversed the gallbladder abnormalities in 7 of 10 patients. Conclusions. A majority of patients receiving octreotide develop gallbladder abnormalities. Ursodiol appears to reverse the abnormalities in most cases.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Clinical Ultrasound|
|State||Published - Jul 1 1998|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging