Sparse multi-task regression and feature selection to identify brain imaging predictors for memory performance

Hua Wang, Feiping Nie, Heng Huang, Shannon Risacher, Chris Ding, Andrew J. Saykin, Li Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

88 Scopus citations

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairment of memory and other cognitive functions, which makes regression analysis a suitable model to study whether neuroimaging measures can help predict memory performance and track the progression of AD. Existing memory performance prediction methods via regression, however, do not take into account either the interconnected structures within imaging data or those among memory scores, which inevitably restricts their predictive capabilities. To bridge this gap, we propose a novel Sparse Multi-tAsk Regression and feaTure selection (SMART) method to jointly analyze all the imaging and clinical data under a single regression framework and with shared underlying sparse representations. Two convex regularizations are combined and used in the model to enable sparsity as well as facilitate multi-task learning. The effectiveness of the proposed method is demonstrated by both clearly improved prediction performances in all empirical test cases and a compact set of selected RAVLT-relevant MRI predictors that accord with prior studies.

Original languageEnglish (US)
Title of host publication2011 International Conference on Computer Vision, ICCV 2011
Pages557-562
Number of pages6
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE International Conference on Computer Vision, ICCV 2011 - Barcelona, Spain
Duration: Nov 6 2011Nov 13 2011

Publication series

NameProceedings of the IEEE International Conference on Computer Vision

Other

Other2011 IEEE International Conference on Computer Vision, ICCV 2011
CountrySpain
CityBarcelona
Period11/6/1111/13/11

ASJC Scopus subject areas

  • Software
  • Computer Vision and Pattern Recognition

Fingerprint Dive into the research topics of 'Sparse multi-task regression and feature selection to identify brain imaging predictors for memory performance'. Together they form a unique fingerprint.

  • Cite this

    Wang, H., Nie, F., Huang, H., Risacher, S., Ding, C., Saykin, A. J., & Shen, L. (2011). Sparse multi-task regression and feature selection to identify brain imaging predictors for memory performance. In 2011 International Conference on Computer Vision, ICCV 2011 (pp. 557-562). [6126288] (Proceedings of the IEEE International Conference on Computer Vision). https://doi.org/10.1109/ICCV.2011.6126288