Spatial distribution of phase singularities in ventricular fibrillation

Miguel Valderrábano, Peng-Sheng Chen, Shien-Fong Lin

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background - Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs) - locations of ambiguous activation state - underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS formation might be important in the development of effective therapies for sudden death. Methods and Results - We performed voltage, phase, and PS mapping in fibrillating ventricles, applying an automated PS detection algorithm to optically recorded fibrillation signals. PS clustering was noted along epicardial vessels, ridges of endocardial trabeculae, and papillary muscle insertions. Microscopically, these locations correlated with areas of apposition of fibers with different angulations and intramural vessels. A total of 83.2% of PSs were formed at and meandered about these anatomic structures, which acted as stabilizers: PSs colocalizing at anatomic substrates had longer life spans than nonanatomic PS (82.46 ± 60.8 versus 40.5 ± 31.9 ms, P

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalCirculation
Volume108
Issue number3
DOIs
StatePublished - Jul 22 2003
Externally publishedYes

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Ventricular Fibrillation
Papillary Muscles
Sudden Death
Cluster Analysis
Therapeutics

Keywords

  • Arrhythmia
  • Fibrillation
  • Waves

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Spatial distribution of phase singularities in ventricular fibrillation. / Valderrábano, Miguel; Chen, Peng-Sheng; Lin, Shien-Fong.

In: Circulation, Vol. 108, No. 3, 22.07.2003, p. 354-359.

Research output: Contribution to journalArticle

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N2 - Background - Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs) - locations of ambiguous activation state - underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS formation might be important in the development of effective therapies for sudden death. Methods and Results - We performed voltage, phase, and PS mapping in fibrillating ventricles, applying an automated PS detection algorithm to optically recorded fibrillation signals. PS clustering was noted along epicardial vessels, ridges of endocardial trabeculae, and papillary muscle insertions. Microscopically, these locations correlated with areas of apposition of fibers with different angulations and intramural vessels. A total of 83.2% of PSs were formed at and meandered about these anatomic structures, which acted as stabilizers: PSs colocalizing at anatomic substrates had longer life spans than nonanatomic PS (82.46 ± 60.8 versus 40.5 ± 31.9 ms, P

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