Spatial gradients controlling spindle assembly

Lesley N. Weaver, Claire Walczak

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function.

Original languageEnglish
Article number0430007
Pages (from-to)7-12
Number of pages6
JournalBiochemical Society Transactions
Volume43
DOIs
StatePublished - Feb 1 2015

Fingerprint

Spindle Apparatus
Chromosomes
Guanosine Triphosphate
Morphogenesis
Self assembly

Keywords

  • Aurora B
  • Microtubule
  • Ran
  • Spindle

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

Cite this

Spatial gradients controlling spindle assembly. / Weaver, Lesley N.; Walczak, Claire.

In: Biochemical Society Transactions, Vol. 43, 0430007, 01.02.2015, p. 7-12.

Research output: Contribution to journalArticle

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