Spatial gradients controlling spindle assembly

Lesley N. Weaver, Claire E. Walczak

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function.

Original languageEnglish (US)
Article number0430007
Pages (from-to)7-12
Number of pages6
JournalBiochemical Society Transactions
Volume43
DOIs
StatePublished - Feb 1 2015

Keywords

  • Aurora B
  • Microtubule
  • Ran
  • Spindle

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

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