Spatial localization of cortical time-frequency dynamics

Sarang S. Dalal, Adrian G. Guggisberg, Erik Edwards, Kensuke Sekihara, Anne M. Findlay, Ryan T. Canolty, Robert T. Knight, Nicholas Barbaro, Heidi E. Kirsch, Srikantan S. Nagarajan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

The spatiotemporal dynamics of cortical oscillations across human brain regions remain poorly understood because of a lack of adequately validated methods for reconstructing such activity from noninvasive electrophysiological data. We present a novel adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction from magnetoencephalography (MEG) and electroencephalography (EEG) data. The efficacy of the method is demonstrated with real MEG data from a self-paced finger movement task. The algorithm reliably reveals modulations both in the beta band (12-30 Hz) and a high gamma band (65-90 Hz) in sensorimotor cortex. The performance is validated by both across-subjects statistical comparisons and by intracranial electrocorticography (ECoG) data from two epilepsy patients. We also revealed observed high gamma activity in the cerebellum. The proposed algorithm is highly parallelizable and runs efficiently on modern high performance computing clusters. This method enables noninvasive five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages4941-4944
Number of pages4
DOIs
StatePublished - 2007
Externally publishedYes
Event29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France
Duration: Aug 23 2007Aug 26 2007

Other

Other29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
CountryFrance
CityLyon
Period8/23/078/26/07

Fingerprint

Magnetoencephalography
Brain
Cluster computing
Electroencephalography
Modulation
Imaging techniques

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Dalal, S. S., Guggisberg, A. G., Edwards, E., Sekihara, K., Findlay, A. M., Canolty, R. T., ... Nagarajan, S. S. (2007). Spatial localization of cortical time-frequency dynamics. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (pp. 4941-4944). [4353449] https://doi.org/10.1109/IEMBS.2007.4353449

Spatial localization of cortical time-frequency dynamics. / Dalal, Sarang S.; Guggisberg, Adrian G.; Edwards, Erik; Sekihara, Kensuke; Findlay, Anne M.; Canolty, Ryan T.; Knight, Robert T.; Barbaro, Nicholas; Kirsch, Heidi E.; Nagarajan, Srikantan S.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 4941-4944 4353449.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dalal, SS, Guggisberg, AG, Edwards, E, Sekihara, K, Findlay, AM, Canolty, RT, Knight, RT, Barbaro, N, Kirsch, HE & Nagarajan, SS 2007, Spatial localization of cortical time-frequency dynamics. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings., 4353449, pp. 4941-4944, 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07, Lyon, France, 8/23/07. https://doi.org/10.1109/IEMBS.2007.4353449
Dalal SS, Guggisberg AG, Edwards E, Sekihara K, Findlay AM, Canolty RT et al. Spatial localization of cortical time-frequency dynamics. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. p. 4941-4944. 4353449 https://doi.org/10.1109/IEMBS.2007.4353449
Dalal, Sarang S. ; Guggisberg, Adrian G. ; Edwards, Erik ; Sekihara, Kensuke ; Findlay, Anne M. ; Canolty, Ryan T. ; Knight, Robert T. ; Barbaro, Nicholas ; Kirsch, Heidi E. ; Nagarajan, Srikantan S. / Spatial localization of cortical time-frequency dynamics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2007. pp. 4941-4944
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