Spatial localization of cortical time-frequency dynamics

Sarang S. Dalal, Adrian G. Guggisberg, Erik Edwards, Kensuke Sekihara, Anne M. Findlay, Ryan T. Canolty, Robert T. Knight, Nicholas M. Barbaro, Heidi E. Kirsch, Srikantan S. Nagarajan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

The spatiotemporal dynamics of cortical oscillations across human brain regions remain poorly understood because of a lack of adequately validated methods for reconstructing such activity from noninvasive electrophysiological data. We present a novel adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction from magnetoencephalography (MEG) and electroencephalography (EEG) data. The efficacy of the method is demonstrated with real MEG data from a self-paced finger movement task. The algorithm reliably reveals modulations both in the beta band (12-30 Hz) and a high gamma band (65-90 Hz) in sensorimotor cortex. The performance is validated by both across-subjects statistical comparisons and by intracranial electrocorticography (ECoG) data from two epilepsy patients. We also revealed observed high gamma activity in the cerebellum. The proposed algorithm is highly parallelizable and runs efficiently on modern high performance computing clusters. This method enables noninvasive five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics.

Original languageEnglish (US)
Title of host publication29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
Pages4941-4944
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 - Lyon, France
Duration: Aug 23 2007Aug 26 2007

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Other

Other29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07
CountryFrance
CityLyon
Period8/23/078/26/07

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Spatial localization of cortical time-frequency dynamics'. Together they form a unique fingerprint.

  • Cite this

    Dalal, S. S., Guggisberg, A. G., Edwards, E., Sekihara, K., Findlay, A. M., Canolty, R. T., Knight, R. T., Barbaro, N. M., Kirsch, H. E., & Nagarajan, S. S. (2007). Spatial localization of cortical time-frequency dynamics. In 29th Annual International Conference of IEEE-EMBS, Engineering in Medicine and Biology Society, EMBC'07 (pp. 4941-4944). [4353449] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2007.4353449