Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle

Further evidence for the quasiperiodic route to chaos hypothesis

Young Hoon Kim, Alan Garfinkel, Takanori Ikeda, Tsu Juey Wu, Charles A. Athill, James N. Weiss, Hrayr S. Karagueuzian, Peng-Sheng Chen

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We have presented evidence that ventricular fibrillation is deterministic chaos arising from quasiperiodicity. The purpose of this study was to determine whether the transition from chaos (ventricular fibrillation, VF) to periodicity (ventricular tachycardia) through quasiperiodicity could be produced by the progressive reduction of tissue mass. In isolated and perfused swine right ventricular free wall, recording of single cell transmembrane potentials and simultaneous mapping (477 bipolar electrodes, 1.6 mm resolution) were performed. The tissue mass was then progressively reduced by sequential cutting. All isolated tissues fibrillated spontaneously. The critical mass to sustain VF was 19.9±4.2 g. As tissue mass was decreased, the number of wave fronts decreased, the life-span of reentrant wave fronts increased, and the cycle length, the diastolic interval, and the duration of action potential lengthened. There was a parallel decrease in the dynamical complexity of VF as measured by Kolmogorov entropy and Poincare plots. A period of quasiperiodicity became more evident before the conversion from VF (chaos) to a more regular arrhythmia (periodicity). In conclusion, a decrease in the number of wave fronts in ventricular fibrillation by tissue mass reduction causes a transition from chaotic to periodic dynamics via the quasiperiodic route.

Original languageEnglish (US)
Pages (from-to)2486-2500
Number of pages15
JournalJournal of Clinical Investigation
Volume100
Issue number10
StatePublished - Nov 15 1997
Externally publishedYes

Fingerprint

Ventricular Fibrillation
Heart Ventricles
Swine
Periodicity
Entropy
Ventricular Tachycardia
Membrane Potentials
Action Potentials
Cardiac Arrhythmias
Electrodes

Keywords

  • Action potentials, G7.453.697.100+
  • Activation analysis, E5.196.39
  • Electrophysiology, G1.344.528
  • Mathematics; H1.548+
  • Tachycardia, ventricular, C14.280.67.845.940

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle : Further evidence for the quasiperiodic route to chaos hypothesis. / Kim, Young Hoon; Garfinkel, Alan; Ikeda, Takanori; Wu, Tsu Juey; Athill, Charles A.; Weiss, James N.; Karagueuzian, Hrayr S.; Chen, Peng-Sheng.

In: Journal of Clinical Investigation, Vol. 100, No. 10, 15.11.1997, p. 2486-2500.

Research output: Contribution to journalArticle

Kim, Young Hoon ; Garfinkel, Alan ; Ikeda, Takanori ; Wu, Tsu Juey ; Athill, Charles A. ; Weiss, James N. ; Karagueuzian, Hrayr S. ; Chen, Peng-Sheng. / Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle : Further evidence for the quasiperiodic route to chaos hypothesis. In: Journal of Clinical Investigation. 1997 ; Vol. 100, No. 10. pp. 2486-2500.
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