Spatiotemporal imaging of cortical activation during verb generation and picture naming

Erik Edwards, Srikantan S. Nagarajan, Sarang S. Dalal, Ryan T. Canolty, Heidi E. Kirsch, Nicholas M. Barbaro, Robert T. Knight

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

One hundred and fifty years of neurolinguistic research has identified the key structures in the human brain that support language. However, neither the classic neuropsychological approaches introduced by Broca (1861) and Wernicke (1874), nor modern neuroimaging employing PET and fMRI has been able to delineate the temporal flow of language processing in the human brain. We recorded the electrocorticogram (ECoG) from indwelling electrodes over left hemisphere language cortices during two common language tasks, verb generation and picture naming. We observed that the very high frequencies of the ECoG (high-gamma, 70-160 Hz) track language processing with spatial and temporal precision. Serial progression of activations is seen at a larger timescale, showing distinct stages of perception, semantic association/selection, and speech production. Within the areas supporting each of these larger processing stages, parallel (or "incremental") processing is observed. In addition to the traditional posterior vs. anterior localization for speech perception vs. production, we provide novel evidence for the role of premotor cortex in speech perception and of Wernicke's and surrounding cortex in speech production. The data are discussed with regards to current leading models of speech perception and production, and a "dual ventral stream" hybrid of leading speech perception models is given.

Original languageEnglish (US)
Pages (from-to)291-301
Number of pages11
JournalNeuroImage
Volume50
Issue number1
DOIs
StatePublished - Mar 1 2010

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Speech Perception
Language
Motor Cortex
Brain
Semantics
Neuroimaging
Electrodes
Magnetic Resonance Imaging
Research

Keywords

  • Electrocorticography
  • Epilepsy
  • High-gamma
  • Language
  • Speech

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Edwards, E., Nagarajan, S. S., Dalal, S. S., Canolty, R. T., Kirsch, H. E., Barbaro, N. M., & Knight, R. T. (2010). Spatiotemporal imaging of cortical activation during verb generation and picture naming. NeuroImage, 50(1), 291-301. https://doi.org/10.1016/j.neuroimage.2009.12.035

Spatiotemporal imaging of cortical activation during verb generation and picture naming. / Edwards, Erik; Nagarajan, Srikantan S.; Dalal, Sarang S.; Canolty, Ryan T.; Kirsch, Heidi E.; Barbaro, Nicholas M.; Knight, Robert T.

In: NeuroImage, Vol. 50, No. 1, 01.03.2010, p. 291-301.

Research output: Contribution to journalArticle

Edwards, E, Nagarajan, SS, Dalal, SS, Canolty, RT, Kirsch, HE, Barbaro, NM & Knight, RT 2010, 'Spatiotemporal imaging of cortical activation during verb generation and picture naming', NeuroImage, vol. 50, no. 1, pp. 291-301. https://doi.org/10.1016/j.neuroimage.2009.12.035
Edwards E, Nagarajan SS, Dalal SS, Canolty RT, Kirsch HE, Barbaro NM et al. Spatiotemporal imaging of cortical activation during verb generation and picture naming. NeuroImage. 2010 Mar 1;50(1):291-301. https://doi.org/10.1016/j.neuroimage.2009.12.035
Edwards, Erik ; Nagarajan, Srikantan S. ; Dalal, Sarang S. ; Canolty, Ryan T. ; Kirsch, Heidi E. ; Barbaro, Nicholas M. ; Knight, Robert T. / Spatiotemporal imaging of cortical activation during verb generation and picture naming. In: NeuroImage. 2010 ; Vol. 50, No. 1. pp. 291-301.
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