Species-, serogroup-, and serovar-specific epitopes are juxtaposed in variable sequence region 4 of the major outer membrane proteins of some Chlamydia trachomatis serovars

Byron E. Batteiger, Pei Mao Lin, Robert B. Jones, Barbara J. Van Der Pol

Research output: Contribution to journalArticle

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Abstract

Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B- serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific epitopes. The carboxyl-terminal portion of variable sequence region 4 (residues 297 to 314) comprises a region of end-to-end B- cell epitopes in some serovars of the B and F/G serogroups.

Original languageEnglish (US)
Pages (from-to)2839-2841
Number of pages3
JournalInfection and immunity
Volume64
Issue number7
StatePublished - Jul 19 1996

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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