Specific inhibitory activity against granulocyte-progenitor cells produced by non-T lymphocytes from patients with neutropenia

Hal Broxmeyer, R. Pahwa, N. Jacobsen, Louis Pelus, P. Ralph, P. A. Meyers, S. Pahwa, N. Kapoor

Research output: Contribution to journalArticle

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Abstract

Bone marrow and peripheral blood cells of patients with non-leukemic neutropenia contain and elaborate a granulocyte-progenitor cell inhibitory activity. The inhibitory activity is common to the neutropenias of the various etiologies studied, which included congenital, idiopathic, autoimmune, cyclical, common variable immuno-deficiency with hypogammaglobulinemia and drug induced states. It derives from non-adherent, low density, slowly sedimenting and non-E-rosetting cells and appears to require RNA and protein synthesis, but not cell division, for its production. The material is not species specific, inhibits autologous and allogeneic normal CFUgm and leukemic CFUgm, is not cell-cycle specific in action and is most effective against granulocyte colony forming cells (CFUg), less effective against mixed granulocyte-macrophage colony forming cells (CFUgm) and least or non- effective against macrophage colony forming cells (CFUm). This inhibitory activity has no influence on cells which generate CFUc in suspension culture or on the erythroid colony forming (CFUe) and burst forming (BFUe) units. It is different from other known inhibitory activities such as lactoferrin, leukemia inhibitory activity, E type prostaglandins, interferon and immunoglobulins. This inhibitory activity, while at present an in vitro phenomenon, may be produced as a secondary response within a compromised host.

Original languageEnglish (US)
Pages (from-to)278-297
Number of pages20
JournalExperimental Hematology
Volume8
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Granulocyte Precursor Cells
Neutropenia
Lymphocytes
Granulocytes
Macrophages
Agammaglobulinemia
Lactoferrin
Prostaglandins E
Cell Division
Interferons
Immunoglobulin E
Blood Cells
Suspensions
Cell Cycle
Leukemia
Bone Marrow
RNA
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Specific inhibitory activity against granulocyte-progenitor cells produced by non-T lymphocytes from patients with neutropenia. / Broxmeyer, Hal; Pahwa, R.; Jacobsen, N.; Pelus, Louis; Ralph, P.; Meyers, P. A.; Pahwa, S.; Kapoor, N.

In: Experimental Hematology, Vol. 8, No. 3, 1980, p. 278-297.

Research output: Contribution to journalArticle

Broxmeyer, H, Pahwa, R, Jacobsen, N, Pelus, L, Ralph, P, Meyers, PA, Pahwa, S & Kapoor, N 1980, 'Specific inhibitory activity against granulocyte-progenitor cells produced by non-T lymphocytes from patients with neutropenia', Experimental Hematology, vol. 8, no. 3, pp. 278-297.
Broxmeyer, Hal ; Pahwa, R. ; Jacobsen, N. ; Pelus, Louis ; Ralph, P. ; Meyers, P. A. ; Pahwa, S. ; Kapoor, N. / Specific inhibitory activity against granulocyte-progenitor cells produced by non-T lymphocytes from patients with neutropenia. In: Experimental Hematology. 1980 ; Vol. 8, No. 3. pp. 278-297.
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