SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder

J. Douglas Bremner, Robert B. Innis, Thomas White, Masahiro Fujita, David Silbersweig, Andrew W. Goddard, Lawrence Staib, Emily Stern, Angela Cappiello, Scott Woods, Ronald Baldwin, Dennis S. Charney

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Background: Alterations in benzodiazepine receptor function have long been hypothesized to play a role in anxiety. Animal models of anxiety involving exposure to chronic stress have shown a specific decrease in benzodiazepine receptor binding in frontal cortex and hippocampus. The purpose of this study was to examine benzodiazepine receptor binding patients with panic disorder and comparison subjects. Methods: A quantitative measure related to benzodiazepine receptor binding (Distribution Volume (DV)) was obtained with single photon emission computed tomography (SPECT) imaging of [123I]iomazenil and measurement of radioligand concentration in plasma in patients with panic disorder and healthy controls. DV image data were analyzed using statistical parametric mapping (spm96). Results: A decrease in measures of benzodiazepine receptor binding (DV) was found in left hippocampus and precuneus in panic disorder patients relative to controls. Panic disorder patients who had a panic attack compared to patients who did not have a panic attack at the time of the scan had a decrease in benzodiazepine receptor binding in prefrontal cortex. Conclusions: Findings of a decrease in left hippocampal and precuneus benzodiazepine receptor binding may be related to alterations in benzodiazepine receptor binding, or other factors including changes in GABAergic transmission or possible endogenous benzodiazepine compounds. Benzodiazepine receptor function in prefrontal cortex appears to be involved in changes in state-related panic anxiety. (C) 2000 Society of Biological Psychiatry.

Original languageEnglish (US)
Pages (from-to)96-106
Number of pages11
JournalBiological Psychiatry
Volume47
Issue number2
DOIs
StatePublished - Jan 15 2000
Externally publishedYes

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Panic Disorder
GABA-A Receptors
Single-Photon Emission-Computed Tomography
Parietal Lobe
Anxiety
Prefrontal Cortex
Hippocampus
iomazenil
Panic
Frontal Lobe
Benzodiazepines
Animal Models

Keywords

  • Benzodiazepines
  • Neuroimaging
  • Panic disorder
  • SPECT

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Bremner, J. D., Innis, R. B., White, T., Fujita, M., Silbersweig, D., Goddard, A. W., ... Charney, D. S. (2000). SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry, 47(2), 96-106. https://doi.org/10.1016/S0006-3223(99)00188-2

SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. / Bremner, J. Douglas; Innis, Robert B.; White, Thomas; Fujita, Masahiro; Silbersweig, David; Goddard, Andrew W.; Staib, Lawrence; Stern, Emily; Cappiello, Angela; Woods, Scott; Baldwin, Ronald; Charney, Dennis S.

In: Biological Psychiatry, Vol. 47, No. 2, 15.01.2000, p. 96-106.

Research output: Contribution to journalArticle

Bremner, JD, Innis, RB, White, T, Fujita, M, Silbersweig, D, Goddard, AW, Staib, L, Stern, E, Cappiello, A, Woods, S, Baldwin, R & Charney, DS 2000, 'SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder', Biological Psychiatry, vol. 47, no. 2, pp. 96-106. https://doi.org/10.1016/S0006-3223(99)00188-2
Bremner JD, Innis RB, White T, Fujita M, Silbersweig D, Goddard AW et al. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry. 2000 Jan 15;47(2):96-106. https://doi.org/10.1016/S0006-3223(99)00188-2
Bremner, J. Douglas ; Innis, Robert B. ; White, Thomas ; Fujita, Masahiro ; Silbersweig, David ; Goddard, Andrew W. ; Staib, Lawrence ; Stern, Emily ; Cappiello, Angela ; Woods, Scott ; Baldwin, Ronald ; Charney, Dennis S. / SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. In: Biological Psychiatry. 2000 ; Vol. 47, No. 2. pp. 96-106.
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AU - Staib, Lawrence

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