Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex

Zizheng Dong, Jing Qi, Hui Peng, Jianguo Liu, Jian Ting Zhang

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: eIF3a (eukaryotic initiation factor 3a), the largest subunit of eIF3, contains three putative protein-binding domains. Results: The spectrin domain of eIF3a binds directly to eIF3i and eIF3b concurrently and indirectly to eIF3g via eIF3b. Conclusion: The spectrin domain of eIF3a is responsible for eIF3(a:b:i:g) subcomplex formation. Significance: Identification of the binding sites helps therapeutic discovery targeting protein-protein interactions in eIF3.

Original languageEnglish (US)
Pages (from-to)27951-27959
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number39
DOIs
StatePublished - Sep 27 2013

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this