Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States

Lisa M. Glass, David C. Whitcomb, Dhiraj Yadav, Joseph Romagnuolo, Elizabeth Kennard, Adam A. Slivka, Randall E. Brand, Michelle A. Anderson, Peter A. Banks, Michele D. Lewis, John Baillie, Stuart Sherman, Samer Alkaade, Stephen T. Amann, James A. Disario, Michael O'Connell, Andres Gelrud, Christopher E. Forsmark, Timothy B. Gardner

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: This study aims to describe the frequency of use and reported effectiveness of endoscopic and surgical therapies in patients with chronic pancreatitis treated at US referral centers. METHODS: Five hundred fifteen patients were enrolled prospectively in the North American Pancreatitis Study 2, where patients and treating physicians reported previous therapeutic interventions and their perceived effectiveness. We evaluated the frequency and effectiveness of endoscopic (biliary or pancreatic sphincterotomy, biliary or pancreatic stent placement) and surgical (pancreatic cyst removal, pancreatic drainage procedure, pancreatic resection, surgical sphincterotomy) therapies. RESULTS: Biliary and/or pancreatic sphincterotomy (42%) were the most common endoscopic procedure (biliary stent, 14%; pancreatic stent, 36%; P <0.001). Endoscopic procedures were equally effective (biliary sphincterotomy, 40.0%; biliary stent, 40.8%; pancreatic stent, 47.0%; P = 0.34). On multivariable analysis, the presence of abdominal pain (odds ratio, 1.82; 95% confidence interval, 1.15-2.88) predicted endoscopy, whereas exocrine insufficiency (odds ratio, 0.63; 95% confidence interval, 0.42-0.94) deterred endoscopy. Surgical therapies were attempted equally (cyst removal, 7%; drainage procedure, 10%; resection procedure, 12%) except for surgical sphincteroplasty (4%; P <0.001). Surgical sphincteroplasty was the least effective (46%; P <0.001) versus cyst removal (76% drainage [71%] and resection [73%]). CONCLUSIONS: Although surgical therapies were performed less frequently than endoscopic therapies, they were more often reported to be effective.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalPancreas
Volume43
Issue number4
DOIs
StatePublished - 2014

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Chronic Pancreatitis
Stents
Drainage
Endoscopy
Cysts
Therapeutics
Odds Ratio
Pancreatic Cyst
Confidence Intervals
Pancreatitis
Abdominal Pain
Referral and Consultation
Physicians

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Glass, L. M., Whitcomb, D. C., Yadav, D., Romagnuolo, J., Kennard, E., Slivka, A. A., ... Gardner, T. B. (2014). Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States. Pancreas, 43(4), 539-543. https://doi.org/10.1097/MPA.0000000000000122

Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States. / Glass, Lisa M.; Whitcomb, David C.; Yadav, Dhiraj; Romagnuolo, Joseph; Kennard, Elizabeth; Slivka, Adam A.; Brand, Randall E.; Anderson, Michelle A.; Banks, Peter A.; Lewis, Michele D.; Baillie, John; Sherman, Stuart; Alkaade, Samer; Amann, Stephen T.; Disario, James A.; O'Connell, Michael; Gelrud, Andres; Forsmark, Christopher E.; Gardner, Timothy B.

In: Pancreas, Vol. 43, No. 4, 2014, p. 539-543.

Research output: Contribution to journalArticle

Glass, LM, Whitcomb, DC, Yadav, D, Romagnuolo, J, Kennard, E, Slivka, AA, Brand, RE, Anderson, MA, Banks, PA, Lewis, MD, Baillie, J, Sherman, S, Alkaade, S, Amann, ST, Disario, JA, O'Connell, M, Gelrud, A, Forsmark, CE & Gardner, TB 2014, 'Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States', Pancreas, vol. 43, no. 4, pp. 539-543. https://doi.org/10.1097/MPA.0000000000000122
Glass, Lisa M. ; Whitcomb, David C. ; Yadav, Dhiraj ; Romagnuolo, Joseph ; Kennard, Elizabeth ; Slivka, Adam A. ; Brand, Randall E. ; Anderson, Michelle A. ; Banks, Peter A. ; Lewis, Michele D. ; Baillie, John ; Sherman, Stuart ; Alkaade, Samer ; Amann, Stephen T. ; Disario, James A. ; O'Connell, Michael ; Gelrud, Andres ; Forsmark, Christopher E. ; Gardner, Timothy B. / Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States. In: Pancreas. 2014 ; Vol. 43, No. 4. pp. 539-543.
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AU - Glass, Lisa M.

AU - Whitcomb, David C.

AU - Yadav, Dhiraj

AU - Romagnuolo, Joseph

AU - Kennard, Elizabeth

AU - Slivka, Adam A.

AU - Brand, Randall E.

AU - Anderson, Michelle A.

AU - Banks, Peter A.

AU - Lewis, Michele D.

AU - Baillie, John

AU - Sherman, Stuart

AU - Alkaade, Samer

AU - Amann, Stephen T.

AU - Disario, James A.

AU - O'Connell, Michael

AU - Gelrud, Andres

AU - Forsmark, Christopher E.

AU - Gardner, Timothy B.

PY - 2014

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N2 - OBJECTIVE: This study aims to describe the frequency of use and reported effectiveness of endoscopic and surgical therapies in patients with chronic pancreatitis treated at US referral centers. METHODS: Five hundred fifteen patients were enrolled prospectively in the North American Pancreatitis Study 2, where patients and treating physicians reported previous therapeutic interventions and their perceived effectiveness. We evaluated the frequency and effectiveness of endoscopic (biliary or pancreatic sphincterotomy, biliary or pancreatic stent placement) and surgical (pancreatic cyst removal, pancreatic drainage procedure, pancreatic resection, surgical sphincterotomy) therapies. RESULTS: Biliary and/or pancreatic sphincterotomy (42%) were the most common endoscopic procedure (biliary stent, 14%; pancreatic stent, 36%; P <0.001). Endoscopic procedures were equally effective (biliary sphincterotomy, 40.0%; biliary stent, 40.8%; pancreatic stent, 47.0%; P = 0.34). On multivariable analysis, the presence of abdominal pain (odds ratio, 1.82; 95% confidence interval, 1.15-2.88) predicted endoscopy, whereas exocrine insufficiency (odds ratio, 0.63; 95% confidence interval, 0.42-0.94) deterred endoscopy. Surgical therapies were attempted equally (cyst removal, 7%; drainage procedure, 10%; resection procedure, 12%) except for surgical sphincteroplasty (4%; P <0.001). Surgical sphincteroplasty was the least effective (46%; P <0.001) versus cyst removal (76% drainage [71%] and resection [73%]). CONCLUSIONS: Although surgical therapies were performed less frequently than endoscopic therapies, they were more often reported to be effective.

AB - OBJECTIVE: This study aims to describe the frequency of use and reported effectiveness of endoscopic and surgical therapies in patients with chronic pancreatitis treated at US referral centers. METHODS: Five hundred fifteen patients were enrolled prospectively in the North American Pancreatitis Study 2, where patients and treating physicians reported previous therapeutic interventions and their perceived effectiveness. We evaluated the frequency and effectiveness of endoscopic (biliary or pancreatic sphincterotomy, biliary or pancreatic stent placement) and surgical (pancreatic cyst removal, pancreatic drainage procedure, pancreatic resection, surgical sphincterotomy) therapies. RESULTS: Biliary and/or pancreatic sphincterotomy (42%) were the most common endoscopic procedure (biliary stent, 14%; pancreatic stent, 36%; P <0.001). Endoscopic procedures were equally effective (biliary sphincterotomy, 40.0%; biliary stent, 40.8%; pancreatic stent, 47.0%; P = 0.34). On multivariable analysis, the presence of abdominal pain (odds ratio, 1.82; 95% confidence interval, 1.15-2.88) predicted endoscopy, whereas exocrine insufficiency (odds ratio, 0.63; 95% confidence interval, 0.42-0.94) deterred endoscopy. Surgical therapies were attempted equally (cyst removal, 7%; drainage procedure, 10%; resection procedure, 12%) except for surgical sphincteroplasty (4%; P <0.001). Surgical sphincteroplasty was the least effective (46%; P <0.001) versus cyst removal (76% drainage [71%] and resection [73%]). CONCLUSIONS: Although surgical therapies were performed less frequently than endoscopic therapies, they were more often reported to be effective.

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