Sphincter of Oddi Dysfunction

Dana C. Moffatt, Stuart Sherman, Evan L. Fogel

Research output: Chapter in Book/Report/Conference proceedingChapter


Sphincter of Oddi dysfunction (SOD) refers to a motor abnormality of the sphincter of Oddi, typically resulting in a hypertonic sphincter, and may be manifested clinically by chronic abdominal pain, pancreatitis, or abnormal liver function tests. In this review, we discuss the classification systems typically used in SOD, as well as the epidemiology of this controversial disease. The diagnostic criteria for SOD are presented, and the evaluation of patients with suspected SOD is reviewed. Both non-invasive and invasive diagnostic methods are discussed. Sphincter of Oddi manometry (SOM) is the only available method to measure motor activity directly, and is considered to be the gold standard for evaluating patients for SOD. Indications, performance, and complications of this technique are reviewed. Therapy for SOD is discussed, with an evidence-based approach provided.

Original languageEnglish (US)
Title of host publicationTextbook of Clinical Gastroenterology and Hepatology
Subtitle of host publicationSecond Edition
Number of pages6
ISBN (Print)1405191821, 9781405191821
StatePublished - Apr 16 2012


  • Endoscopic retrograde cholangiopancreatography (ERCP)
  • Post-cholecystectomy abdominal pain
  • Post-ERCP pancreatitis
  • Sphincter of Oddi dysfunction
  • Sphincter of Oddi manometry

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Moffatt, D. C., Sherman, S., & Fogel, E. L. (2012). Sphincter of Oddi Dysfunction. In Textbook of Clinical Gastroenterology and Hepatology: Second Edition (pp. 567-572). Wiley-Blackwell. https://doi.org/10.1002/9781118321386.ch75