Sphincter of Oddi dysfunction

Research output: Contribution to journalReview article

49 Scopus citations


Evidence continues to accumulate indicating that sphincter of Oddi dysfunction may give rise to cholestasis, pancreatitis, or upper abdominal pain syndromes. Diagnosis of such dysfunction may be inferred from noninvasive tests or more precisely defined by manometric studies. Both the biliary and pancreatic sphincters are commonly involved. If medical therapy is ineffective, sphincter ablation via endoscopy or laparotomy should be considered for highly symptomatic patients. Complication rates of invasive techniques remain relatively high and risk:benefit ratio should be carefully considered. Future research as to etiology, more defined pathophysiology, more accurate noninvasive evaluation, and optimal therapies are awaited.

Original languageEnglish (US)
Pages (from-to)11-25
Number of pages15
JournalInternational Journal of Pancreatology
Issue number1
StatePublished - Sep 14 1996


  • biliary manometry
  • endoscopic retrograde cholangiopancreatography (ERCP)
  • pancreatitis
  • papillary stenosis
  • post cholecystectomy syndrome
  • Sphincter of Oddi

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

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