Spinal osteoporosis in men

R. M. Francis, Munro Peacock, D. H. Marshall, A. Horsman, J. E. Aaron

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

In 94 men with crush fracture, 40 were found to have primary osteoporosis. Cross-sectional measurements of a number of variables related to bone in these 40 patients were compared to the values in various groups of healthy men aged 20-96. In healthy men, metacarpal and femoral cortical area/tolal area, bone volume, osteoid surfaces, seam and trabecular width, plasma dihydroepiandrosterone and estrone, and radiocalcium absorption fell with age, whereas eroded surfaces, trabecular number, urine hydroxyproline and calcium/creatinine ratios, plasma alkaline phosphatase, estradiol, androstenedione, cortisol and testosterone remained constant with age. As compared with healthy men, men with primary osteoporosis had reduced femoral cortical area/total area (P < 0.05), and Singh grade (P < 0.001) and in seven there was a history of forearm or femoral fracture. On iliac crest biopsy, bone volume (P < 0.001) and trabecular number (P < 0.01) were decreased. Plasma alkaline phosphatase (P < 0.02) was increased but urine hydroxyproline and calcium excretion were not significantly raised. Calcium balance was negative due to failure of absorption to match urinary calcium loss and radiocalcium absorption (P < 0.01) and plasma 1,25-dihydroxyvitamin D (P < 0.05) were reduced.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalBone and Mineral
Volume5
Issue number3
DOIs
StatePublished - 1989

Fingerprint

Osteoporosis
Calcium
Plasmas
Bone
Hydroxyproline
Alkaline Phosphatase
Thigh
Bone and Bones
Androstenedione
Biopsy
Estrone
Urine
Metacarpal Bones
Femoral Fractures
Hydrocortisone
Testosterone
Estradiol
Creatinine
Forearm
History

Keywords

  • Age
  • Biochemistry
  • Bone histology
  • Men
  • Osteoporosis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Surgery

Cite this

Francis, R. M., Peacock, M., Marshall, D. H., Horsman, A., & Aaron, J. E. (1989). Spinal osteoporosis in men. Bone and Mineral, 5(3), 347-357. https://doi.org/10.1016/0169-6009(89)90012-3

Spinal osteoporosis in men. / Francis, R. M.; Peacock, Munro; Marshall, D. H.; Horsman, A.; Aaron, J. E.

In: Bone and Mineral, Vol. 5, No. 3, 1989, p. 347-357.

Research output: Contribution to journalArticle

Francis, RM, Peacock, M, Marshall, DH, Horsman, A & Aaron, JE 1989, 'Spinal osteoporosis in men', Bone and Mineral, vol. 5, no. 3, pp. 347-357. https://doi.org/10.1016/0169-6009(89)90012-3
Francis RM, Peacock M, Marshall DH, Horsman A, Aaron JE. Spinal osteoporosis in men. Bone and Mineral. 1989;5(3):347-357. https://doi.org/10.1016/0169-6009(89)90012-3
Francis, R. M. ; Peacock, Munro ; Marshall, D. H. ; Horsman, A. ; Aaron, J. E. / Spinal osteoporosis in men. In: Bone and Mineral. 1989 ; Vol. 5, No. 3. pp. 347-357.
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