Spinocerebellar ataxia: Localization of an autosomal dominant locus between two markers on human chromosome 6

S. S. Rich, P. Wilkie, L. Schut, G. Vance, H. T. Orr

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Inhertied spinocerebellar ataxias (SCA) are progressively degenerative neurological diseases. The primary site of degeneration is the cerebellar cortex - in particular, the Purkinje cells. In the present report, the SCA locus, inherited as an autosomal dominant trait in a large kindred, is localized to a region ~ 15 centimorgans telomeric of HLA-A on the short arm of chromosome 6.

Original languageEnglish (US)
Pages (from-to)524-531
Number of pages8
JournalAmerican Journal of Human Genetics
Volume41
Issue number4
StatePublished - Dec 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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