Spinocerebellar ataxia

Localization of an autosomal dominant locus between two markers on human chromosome 6

S. S. Rich, P. Wilkie, L. Schut, Gail Vance, H. T. Orr

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Inhertied spinocerebellar ataxias (SCA) are progressively degenerative neurological diseases. The primary site of degeneration is the cerebellar cortex - in particular, the Purkinje cells. In the present report, the SCA locus, inherited as an autosomal dominant trait in a large kindred, is localized to a region ~ 15 centimorgans telomeric of HLA-A on the short arm of chromosome 6.

Original languageEnglish (US)
Pages (from-to)524-531
Number of pages8
JournalAmerican Journal of Human Genetics
Volume41
Issue number4
StatePublished - 1987
Externally publishedYes

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Spinocerebellar Ataxias
Chromosomes, Human, Pair 6
Human Chromosomes
Cerebellar Cortex
HLA-A Antigens
Purkinje Cells

ASJC Scopus subject areas

  • Genetics

Cite this

Spinocerebellar ataxia : Localization of an autosomal dominant locus between two markers on human chromosome 6. / Rich, S. S.; Wilkie, P.; Schut, L.; Vance, Gail; Orr, H. T.

In: American Journal of Human Genetics, Vol. 41, No. 4, 1987, p. 524-531.

Research output: Contribution to journalArticle

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