Spirometric pulmonary function in healthy preschool children

Howard Eigen, Harvey Bieler, Debra Grant, Kathy Christoph, Delana Terrill, Douglas K. Heilman, Walter T. Ambrosius, Robert S. Tepper

Research output: Contribution to journalArticle

213 Scopus citations


The purpose of this study was to evaluate spirometric lung function in normal children ages 3 to 6 yr. Spirometric measurements were obtained at nursery and daycare centers by experienced pediatric pulmonary function technicians. Of 307 children recruited, 259 fulfilled our criteria as normal. Of these, 82.6% (214) were able to perform technically acceptable and reproducible maneuvers during a testing session limited to 15 min. The regression model with log-transformed parameters of pulmonary function and height had the best correlations. After accounting for height in the model, other physical traits and health questionnaire items did not contribute significantly. PEFR, FVC, FEV1, and FEF25-75 all increased with increasing height; correlation coefficients were 0.73, 0.93, 0.92, and 0.67, respectively. The group mean coefficients of variation for replicate measurements of PEFR, FVC, FEV1, and FEF25-75 were 7.8%, 2.5%, 2.7%, and 8.3%, respectively. There was a significant decrease in the ratio FEV1/FVC with increasing height; the mean predicted FEV1/FVC was 0.97 at 90 cm height and 0.89 at 125 cm height. In conclusion, reproducible spirometry can be obtained in the majority of preschool children and has the potential to improve our assessment and management of pulmonary disease.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Issue number3 I
StatePublished - 2001

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'Spirometric pulmonary function in healthy preschool children'. Together they form a unique fingerprint.

  • Cite this

    Eigen, H., Bieler, H., Grant, D., Christoph, K., Terrill, D., Heilman, D. K., Ambrosius, W. T., & Tepper, R. S. (2001). Spirometric pulmonary function in healthy preschool children. American journal of respiratory and critical care medicine, 163(3 I), 619-623. https://doi.org/10.1164/ajrccm.163.3.2002054