Spirometry in 3- to 6-year-old children with cystic fibrosis

Paulo J.C. Marostica, Andrea D. Weist, Howard Eigen, Connie Angelicchio, Kathy Christoph, Julie Savage, Debra Grant, Robert S. Tepper

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Spirometry is routinely used to assess pulmonary function of older children and adults with cystic fibrosis (CF); however, few data exist concerning the preschool age group. We have reported normative spirometric data for 3- to 6-year-old children. The current study was designed to assess a similarly aged group of clinically stable patients with CF. Thirty-three of 38 children with CF were able to perform 2 or 3 technically acceptable maneuvers. These patients had significantly decreased FVC, FEV1, FEV1/FVC, and FEF25-75 when expressed as z scores (number of SD from predicted): -0.75 ± 1.63, -1.23 ± 1.97, -0.87 ± 1.33, and -0.74 ± 1.63, respectively. There were significant positive correlations of the Brasfield radiological score with FVC and FEV1 z scores (r2 = 0.26, p < 0.01 and r2 = 0.24, p < 0.01). In addition, homozygous patients for the ΔF508 mutation had lower z scores for FVC (-1.21 versus 0.47, p < 0.01) and FEV1 (-1.38 versus 0.21, p < 0.05) than heterozygous patients. Of the 14 patients who had full flow-volume spirometric measurements during infancy, 10 had FEF25-75 z scores greater than -2 at both evaluations. Our findings suggest that spirometry can successfully be used to assess lung function in preschool children with CF and has the potential for longitudinal assessment from infancy through adulthood.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Issue number1
StatePublished - Jul 1 2002


  • Cystic fibrosis
  • Preschool child
  • Spirometry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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