Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats

W. J. McBride, J. M. Murphy, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The present study was undertaken to determine if spiroxatrine, a reported 5-HT1A antagonist, could block the attenuating effects of fluoxetine (a 5-HT uptake inhibitor) on voluntary ethanol intake by the selectively bred alcohol-preferring P line of rats. Fluoxetine (10 mg/kg, IP) significantly reduced the intake of 10% ethanol by P rats approximately 50% during the 4-hour period of alcohol availability. Spiroxatrine (4 mg/kg, IP) was without effect on ethanol intake when given alone. However, when given 5 minutes before fluoxetine (10 mg/kg, IP), this dose of spiroxatrine augmented the reduction of ethanol intake to approximately 15% of control values after 4 hours. Similar experiments conducted with 1 mg/kg (IP) 8-hydroxy-2(di-N-propylamino) tetralin (DPAT) demonstrated that this 5-HT1A agonist also enhanced the attenuating effects of fluoxetine on ethanol intake. Likewise, spiroxatrine augmented the DPAT reduction of alcohol intake. Spiroxatrine enhanced the effect of DPAT and fluoxetine on food intake as it did on ethanol intake. The results suggest that spiroxatrine behaved as a partial agonist and/or modulator and not as an antagonist at 5-HT1A receptors under the present experimental conditions.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume34
Issue number2
DOIs
StatePublished - 1989

Fingerprint

spiroxatrine
Fluoxetine
Rats
Ethanol
Alcohols
Serotonin 5-HT1 Receptor Antagonists
Serotonin 5-HT1 Receptor Agonists
Receptor, Serotonin, 5-HT1A
Serotonin Uptake Inhibitors
Modulators
Eating

Keywords

  • 8-Hydroxy-2-(di-N-propylamino) tetralin
  • Alcohol drinking
  • Alcohol-preferring rats
  • Fluoxetine
  • Spiroxatrine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. / McBride, W. J.; Murphy, J. M.; Lumeng, L.; Li, T. K.

In: Pharmacology Biochemistry and Behavior, Vol. 34, No. 2, 1989, p. 381-386.

Research output: Contribution to journalArticle

McBride, W. J. ; Murphy, J. M. ; Lumeng, L. ; Li, T. K. / Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. In: Pharmacology Biochemistry and Behavior. 1989 ; Vol. 34, No. 2. pp. 381-386.
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