Splenic Vein Thrombosis Is Associated with an Increase in Pancreas-Specific Complications and Reduced Survival in Patients Undergoing Distal Pancreatectomy for Pancreatic Exocrine Cancer

Nishi Dedania, Nidhi Agrawal, Jordan M. Winter, Leonidas Koniaris, Ernest L. Rosato, Patricia K. Sauter, Ben Leiby, Edward Pequignot, Charles J. Yeo, Harish Lavu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Distal pancreatectomy and splenectomy (DPS) is the procedure of choice for the surgical treatment of pancreatic exocrine cancer localized to the body and tail of the pancreas. Splenic vein thrombosis (SVT) can occur in patients with malignant pancreatic exocrine tumors secondary to direct tumor invasion or compression of the splenic vein by mass effect. This study examines the effect of preoperative SVT on postoperative outcomes. In this retrospective cohort study, we queried our pancreatic surgery database to identify patients who underwent DPS from October 2005 to June 2011. These cases were evaluated for evidence of preoperative SVT on clinical records and cross-sectional imaging (CT, MRI, endoscopic US). Outcomes for patients with and without SVT were compared. From an overall cohort of 285 consecutive patients who underwent DPS during the study period, data were evaluated for 70 subjects who underwent surgery for pancreatic exocrine cancer (27 with SVT, 43 without SVT). The preoperative demographics and co-morbidities were similar between the groups, except the average age was higher for those without SVT (p <0.05). The median estimated blood loss was significantly higher in the SVT group (675 versus 250 ml, p =

Original languageEnglish (US)
Pages (from-to)1392-1398
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume17
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

Fingerprint

Splenic Vein
Pancreatectomy
Pancreatic Neoplasms
Pancreas
Thrombosis
Survival
Splenectomy
Neoplasms
Cohort Studies
Retrospective Studies
Demography
Databases
Morbidity

Keywords

  • Distal pancreatectomy
  • Pancreatic cancer
  • Splenic vein thrombosis

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Splenic Vein Thrombosis Is Associated with an Increase in Pancreas-Specific Complications and Reduced Survival in Patients Undergoing Distal Pancreatectomy for Pancreatic Exocrine Cancer. / Dedania, Nishi; Agrawal, Nidhi; Winter, Jordan M.; Koniaris, Leonidas; Rosato, Ernest L.; Sauter, Patricia K.; Leiby, Ben; Pequignot, Edward; Yeo, Charles J.; Lavu, Harish.

In: Journal of Gastrointestinal Surgery, Vol. 17, No. 8, 08.2013, p. 1392-1398.

Research output: Contribution to journalArticle

Dedania, Nishi ; Agrawal, Nidhi ; Winter, Jordan M. ; Koniaris, Leonidas ; Rosato, Ernest L. ; Sauter, Patricia K. ; Leiby, Ben ; Pequignot, Edward ; Yeo, Charles J. ; Lavu, Harish. / Splenic Vein Thrombosis Is Associated with an Increase in Pancreas-Specific Complications and Reduced Survival in Patients Undergoing Distal Pancreatectomy for Pancreatic Exocrine Cancer. In: Journal of Gastrointestinal Surgery. 2013 ; Vol. 17, No. 8. pp. 1392-1398.
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