Spondyloarthropathies: Update on diagnosis and therapy

Mazen Elyan, Muhammad Asim Khan

Research output: Contribution to journalArticle

1 Scopus citations


The spondyloarthropathies are strongly associated with the HLA-B27 gene. The diagnosis is based primarily on clinical findings. Ankylosing spondylitis often involves the sacroiliac joints and spine. Psoriatic arthritis occurs in up to one-third of patients with psoriasis. Reactive arthritis must be distinguished from other arthropathies. Arthritis occurs in about 30% of patients with inflammatory bowel disease. Undifferentiated spondyloarthropathy includes several related disorders. Radiographic evidence of sacroiliitis is a characteristic feature of ankylosing spondylitis. Management of spondyloarthropathies should include patient education and regular exercise. NSAIDs are the first line of treatment. The tumor necrosis factor-α inhibitors are highly effective in patients with active ankylosing spondylitis and in those with psoriatic arthritis that is unresponsive to conventional therapy.

Original languageEnglish (US)
Pages (from-to)681-691
Number of pages11
Issue number9
StatePublished - Aug 1 2008


  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Reactive arthritis
  • Spondyloarthropathy

ASJC Scopus subject areas

  • Medicine(all)

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