The spondyloarthropathies are strongly associated with the HLA-B27 gene. The diagnosis is based primarily on clinical findings. Ankylosing spondylitis often involves the sacroiliac joints and spine. Psoriatic arthritis occurs in up to one-third of patients with psoriasis. Reactive arthritis must be distinguished from other arthropathies. Arthritis occurs in about 30% of patients with inflammatory bowel disease. Undifferentiated spondyloarthropathy includes several related disorders. Radiographic evidence of sacroiliitis is a characteristic feature of ankylosing spondylitis. Management of spondyloarthropathies should include patient education and regular exercise. NSAIDs are the first line of treatment. The tumor necrosis factor-α inhibitors are highly effective in patients with active ankylosing spondylitis and in those with psoriatic arthritis that is unresponsive to conventional therapy.
|Original language||English (US)|
|Number of pages||11|
|State||Published - Aug 1 2008|
- Ankylosing spondylitis
- Psoriatic arthritis
- Reactive arthritis
ASJC Scopus subject areas