Spontaneous and induced interferon production by peripheral blood leucocytes from control population and patients with herpes genitalis

D. Lannello, M. W. Taylor, K. H. Fife, L. Chen

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The spontaneous and PHA induced levels of interferon were measured in peripheral blood leucocyte cultures of twenty-eight individuals diagnosed as positive for herpes genitalis, and in a group of control subjects. As reported by Cunningham and Merigan [1983] for herpes labialis, leucocytes from individuals with herpes genitalis produced low levels of interferon spontaneously; however, similar results were found for individuals within the control population. No statistically significant difference could be found for PHA induced interferon levels, antigen induced interferon levels, or helper/suppressor cell ratios between the herpes genitalis population and control population. Our results indicated that interferon does not play a major role in the latency or recurrence of herpes genitalis.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalJournal of Medical Virology
Issue number1
StatePublished - May 1987



  • herpes genitalis
  • immune response
  • interferon
  • lymphocyte sub‐types
  • mitogen stimulation
  • viral infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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