Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

Jane Yoo, Miyuki Omori, Dora Gyarmati, Baohua Zhou, Theingi Aye, Avery Brewer, Michael R. Comeau, Daniel J. Campbell, Steven F. Ziegler

Research output: Contribution to journalArticle

423 Scopus citations

Abstract

The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease. JEM

Original languageEnglish (US)
Pages (from-to)541-549
Number of pages9
JournalJournal of Experimental Medicine
Volume202
Issue number4
DOIs
StatePublished - Aug 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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