Spontaneous mammary intraepithelial lesions in dogs - A model of breast cancer

Elisabetta Antuofermo, Margaret A. Miller, Salvatore Pirino, Jun Xie, Sunil Badve, Sulma I. Mohammed

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Mammary intraepithelial lesions (IEL) are nowadays frequently diagnosed as a result of the success of mammographic screening, education programs, and awareness by women. Establishment of an animal model for these lesions to test treatment or preventive modalities is a prerequisite for human clinical trials. A model for spontaneous IELs, especially for estrogen receptor (ER)-negative lesions, does not exist. This study describes the histologic and immunohistochemical similarity between human and canine mammary IELs. Mammary tumors from 200 dogs were classified and histologic sections of the excisional specimens were evaluated for IELs. IELs, found in specimens from 60 dogs, were categorized as adenosis, sclerosing adenosis, intraductal papilloma, sclerosing papilloma, ductal hyperplasia, atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS; high, intermediate, and low grade). Most proliferative IELs without atypia were associated withbenign tumors, whereas IELs withatypia (ADH and DCIS) were generally associated withmammary cancer. ER-α expression was significantly low or absent in most ADH and DCIS lesions as well as in their associated tumors. Ki67 expression was significantly higher in high-grade DCIS than in hyperplasia or low-grade DCIS. Two thirds of high-grade DCIS lesions were positive for HER-2. Canine mammary IELs were strikingly similar to those of the human breast. The frequency of IELs in the dog, their association with spontaneous mammary cancer, their pattern of ER-α and HER-2 expression, and their histologic resemblance to human IELs may make the dog an ideal model to study human ER-negative (both HER-2 positive and negative) breast cancer progression as well as prevention and treatment.

Original languageEnglish
Pages (from-to)2247-2256
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2007

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Carcinoma, Intraductal, Noninfiltrating
Breast
Dogs
Breast Neoplasms
Estrogen Receptors
Canidae
Intraductal Papilloma
Estrogen Receptor beta
Neoplasms
Papilloma
Hyperplasia
Animal Models
Clinical Trials
Education

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Spontaneous mammary intraepithelial lesions in dogs - A model of breast cancer. / Antuofermo, Elisabetta; Miller, Margaret A.; Pirino, Salvatore; Xie, Jun; Badve, Sunil; Mohammed, Sulma I.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 11, 01.11.2007, p. 2247-2256.

Research output: Contribution to journalArticle

Antuofermo, Elisabetta ; Miller, Margaret A. ; Pirino, Salvatore ; Xie, Jun ; Badve, Sunil ; Mohammed, Sulma I. / Spontaneous mammary intraepithelial lesions in dogs - A model of breast cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 11. pp. 2247-2256.
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