Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden death

Shengmei Zhou, Byung Chun Jung, Alex Y. Tan, Vinh Quang Trang, Ghassan Gholmieh, Seong Wook Han, Shien Fong Lin, Michael C. Fishbein, Peng Sheng Chen, Lan S. Chen

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Background: Little information is available on the temporal relationship between instantaneous sympathetic nerve activity and ventricular arrhythmia in ambulatory animals. Objective: The purpose of this study was to determine if increased sympathetic nerve activity precedes the onset of ventricular arrhythmia. Methods: Simultaneous continuous long-term recording of left stellate ganglion (LSG) nerve activity and electrocardiography was performed in eight dogs with nerve growth factor infusion to the LSG, atrioventricular block, and myocardial infarction (experimental group) and in six normal dogs (control group). Results: LSG nerve activity included low-amplitude burst discharge activity (LABDA) and high-amplitude spike discharge activity (HASDA). Both LABDA and HASDA accelerated heart rate. In the experimental group, most ventricular tachycardia (86.3%) and sudden cardiac death were preceded within 15 seconds by either LABDA or HASDA. The closer to onset of ventricular tachycardia, the higher the nerve activity. The majority of HASDA was followed immediately by either ventricular arrhythmia (21%) or QRS morphology changes (65%). HASDA occurred in a circadian pattern. HASDA occurred twice as often in the experimental group than in the control group. Electrical stimulation of LSG increased transmural heterogeneity of repolarization (Tpeak-end intervals) and induced either ventricular tachycardia or fibrillation in the experimental group but not in the control group. Immunohistochemical studies revealed increased synaptogenesis and nerve sprouting in the LSG in the experimental group. Conclusion: Two distinct types of LSG nerve activity (HASDA and LABDA) are present in the LSG of ambulatory dogs. The majority of malignant ventricular arrhythmias are preceded by either HASDA or LABDA, with HASDA particularly arrhythmogenic.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalHeart Rhythm
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Stellate Ganglion
Sudden Death
Canidae
Cardiac Arrhythmias
Ventricular Tachycardia
Dogs
Control Groups
Atrioventricular Block
Sudden Cardiac Death
Ventricular Fibrillation
Nerve Growth Factor
Electric Stimulation
Electrocardiography
Heart Rate
Myocardial Infarction

Keywords

  • Arrhythmia
  • Cardiac electrophysiology
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden death. / Zhou, Shengmei; Jung, Byung Chun; Tan, Alex Y.; Trang, Vinh Quang; Gholmieh, Ghassan; Han, Seong Wook; Lin, Shien Fong; Fishbein, Michael C.; Chen, Peng Sheng; Chen, Lan S.

In: Heart Rhythm, Vol. 5, No. 1, 01.01.2008, p. 131-139.

Research output: Contribution to journalArticle

Zhou, Shengmei ; Jung, Byung Chun ; Tan, Alex Y. ; Trang, Vinh Quang ; Gholmieh, Ghassan ; Han, Seong Wook ; Lin, Shien Fong ; Fishbein, Michael C. ; Chen, Peng Sheng ; Chen, Lan S. / Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden death. In: Heart Rhythm. 2008 ; Vol. 5, No. 1. pp. 131-139.
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T1 - Spontaneous stellate ganglion nerve activity and ventricular arrhythmia in a canine model of sudden death

AU - Zhou, Shengmei

AU - Jung, Byung Chun

AU - Tan, Alex Y.

AU - Trang, Vinh Quang

AU - Gholmieh, Ghassan

AU - Han, Seong Wook

AU - Lin, Shien Fong

AU - Fishbein, Michael C.

AU - Chen, Peng Sheng

AU - Chen, Lan S.

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AB - Background: Little information is available on the temporal relationship between instantaneous sympathetic nerve activity and ventricular arrhythmia in ambulatory animals. Objective: The purpose of this study was to determine if increased sympathetic nerve activity precedes the onset of ventricular arrhythmia. Methods: Simultaneous continuous long-term recording of left stellate ganglion (LSG) nerve activity and electrocardiography was performed in eight dogs with nerve growth factor infusion to the LSG, atrioventricular block, and myocardial infarction (experimental group) and in six normal dogs (control group). Results: LSG nerve activity included low-amplitude burst discharge activity (LABDA) and high-amplitude spike discharge activity (HASDA). Both LABDA and HASDA accelerated heart rate. In the experimental group, most ventricular tachycardia (86.3%) and sudden cardiac death were preceded within 15 seconds by either LABDA or HASDA. The closer to onset of ventricular tachycardia, the higher the nerve activity. The majority of HASDA was followed immediately by either ventricular arrhythmia (21%) or QRS morphology changes (65%). HASDA occurred in a circadian pattern. HASDA occurred twice as often in the experimental group than in the control group. Electrical stimulation of LSG increased transmural heterogeneity of repolarization (Tpeak-end intervals) and induced either ventricular tachycardia or fibrillation in the experimental group but not in the control group. Immunohistochemical studies revealed increased synaptogenesis and nerve sprouting in the LSG in the experimental group. Conclusion: Two distinct types of LSG nerve activity (HASDA and LABDA) are present in the LSG of ambulatory dogs. The majority of malignant ventricular arrhythmias are preceded by either HASDA or LABDA, with HASDA particularly arrhythmogenic.

KW - Arrhythmia

KW - Cardiac electrophysiology

KW - Sympathetic nerve activity

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