Spontaneously Hypertensive Rats: Expression of the Erythrocyte Membrane Proteins in Second Generation Hybrids F2 (SHR x WKY)

A. Yu Kupreeva, A. Y. Postnov, V. P. Ivanov, D. V. Zaretsky, M. V. Zaretskaya

Research output: Contribution to journalArticle

Abstract

The aim of the study was to determine characteristics of phenotype (blood pressure level, heart rate) of second generation hybrids of SHR and WKY rats (F2) and to investigate its relationship with contents of some proteins in erythrocyte membrane. There were significant differences between SHR and WKY rats in quantitative content of a series of membrane protein fractions. Blood pressure level correlated with expression of α- and β-spectrin, some proteins from bands 4.1a, 4.2, 4.5, and tropomyosin. Directions of correlations for some protein fractions were sex related and correlation coefficients for male and female animals had opposite signs. These data demonstrated existence of disturbed regulation of expression of the plasmatic cell membrane proteins in spontaneously hypertensive rats.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalKardiologiya
Volume39
Issue number4
StatePublished - Dec 1 1999
Externally publishedYes

Keywords

  • Erythrocyte
  • F2 hybrids
  • Membrane proteins
  • Spontaneously hypertensive rats (SHR)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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