Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis

Steven R. Schwid, Andrew D. Goodman, J. Edward Puzas, Michael P. McDermott, David Mattson

Research output: Contribution to journalArticle

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Abstract

Background: Bone mineral density is reduced in patients with multiple sclerosis (MS), but the reduction has not been shown to correlate with steroid use retrospectively. Objective: To prospectively measure bone density following a single corticosteroid pulse using dual energy x-ray absorptiometry. Patients and Methods: Thirty acutely relapsing patients with MS were given 1000 mg of methylprednisolone intravenously daily for 3 days followed by an oral prednisone taper for 2 weeks. The bone density was determined at the lumbar spine and femoral neck prior to treatment. Seventeen patients were reevaluated 2, 4, and 6 months following treatment. Results: Prior to treatment, bone density in patients with MS was already reduced at the femoral neck compared with an age matched reference population, but the degree of this reduction did not correlate with prior steroid exposure. Lumbar density, in contrast, was normal. Following the steroid pulse, lumbar bone density increased, becoming 1.7% greater than baseline 6 months later (P=.02). Femoral bone density did not change on average, but the patients who required a cane or walker for ambulation had a 1.6% decrease in femoral bone density, while those with better ambulation had a 2.9% increase (P=.04). Conclusions: Bone density is decreased in MS. A single corticosteroid pulse did not reduce bone density in fully ambulatory patients with MS and multiple pulses did not have a cumulative effect on bone density in retrospective analysis. The change in femoral density in poorly ambulatory patients may have been related to inactivity rather than the steroid pulse.

Original languageEnglish (US)
Pages (from-to)753-757
Number of pages5
JournalArchives of Neurology
Volume53
Issue number8
StatePublished - Aug 1996
Externally publishedYes

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Bone Density
Osteoporosis
Multiple Sclerosis
Adrenal Cortex Hormones
Thigh
Steroids
Femur Neck
Walking
Pulse
Canes
Methylprednisolone
Prednisone
Spine
Therapeutics
X-Rays

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Schwid, S. R., Goodman, A. D., Edward Puzas, J., McDermott, M. P., & Mattson, D. (1996). Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis. Archives of Neurology, 53(8), 753-757.

Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis. / Schwid, Steven R.; Goodman, Andrew D.; Edward Puzas, J.; McDermott, Michael P.; Mattson, David.

In: Archives of Neurology, Vol. 53, No. 8, 08.1996, p. 753-757.

Research output: Contribution to journalArticle

Schwid, SR, Goodman, AD, Edward Puzas, J, McDermott, MP & Mattson, D 1996, 'Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis', Archives of Neurology, vol. 53, no. 8, pp. 753-757.
Schwid SR, Goodman AD, Edward Puzas J, McDermott MP, Mattson D. Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis. Archives of Neurology. 1996 Aug;53(8):753-757.
Schwid, Steven R. ; Goodman, Andrew D. ; Edward Puzas, J. ; McDermott, Michael P. ; Mattson, David. / Sporadic corticosteroid pulses and osteoporosis in multiple sclerosis. In: Archives of Neurology. 1996 ; Vol. 53, No. 8. pp. 753-757.
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