Squamous papilloma of the urinary tract is unrelated to condyloma acuminata

Liang Cheng, Bradley C. Leibovich, John C. Cheville, Dharamdas M. Ramnani, Thomas J. Sebo, Ajay Nehra, Reza S. Malek, Horst Zincke, David G. Bostwick

Research output: Contribution to journalArticle

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Abstract

BACKGROUND. To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma. METHODS. The authors evaluated the clinical and pathologic features of squamous papilloma (5 of the bladder, 2 of the urethra), condyloma acuminatum (3 cases), and verrucous carcinoma (3 cases) of the urinary bladder and performed human papillomavirus (HPV) DNA in situ hybridization studies to determine whether HPV was a common feature shared by these lesions. In addition, DNA ploidy evaluation by image cytometry and p53 immunohistochemical staining were performed. RESULTS. Squamous papilloma of the urinary tract occurred in elderly women and followed a benign clinical course with infrequent recurrence. All squamous papillomas were HPV DNA negative and DNA diploid with no or minimal p53 nuclear accumulation. Condyloma acuminata of the bladder contained HPV DNA, increased p53 protein expression, and aneuploid DNA content. All three cases of condyloma acuminata were associated with coexistent condylomata of the external genitalia, and two required pelvic exenteration for uncontrolled expansile growth. Verrucous carcinoma of the bladder occurred in elderly patients. All three cases of verrucous carcinoma were negative for HPV DNA and DNA aneuploid, and they exhibited consistent p53 expression. CONCLUSIONS. These data indicate that squamous papilloma is a distinct entity not related to condyloma or verrucous carcinoma. These lesions are benign, HPV DNA negative, DNA diploid, and they lack p53 overaccumulation. (C) 2000 American Cancer Society.

Original languageEnglish
Pages (from-to)1679-1686
Number of pages8
JournalCancer
Volume88
Issue number7
DOIs
StatePublished - Apr 1 2000

Fingerprint

Condylomata Acuminata
Papilloma
Urinary Tract
Verrucous Carcinoma
DNA
Urinary Bladder
Aneuploidy
Diploidy
Pelvic Exenteration
Image Cytometry
Genitalia
Ploidies
Urethra
In Situ Hybridization
Staining and Labeling
Recurrence

Keywords

  • Bladder
  • Condylomata acuminata
  • DNA ploidy
  • Human papillomavirus
  • Koilocyte
  • Neoplasms
  • p53
  • Papilloma
  • Precursor
  • Squamous lesion
  • Verrucous carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cheng, L., Leibovich, B. C., Cheville, J. C., Ramnani, D. M., Sebo, T. J., Nehra, A., ... Bostwick, D. G. (2000). Squamous papilloma of the urinary tract is unrelated to condyloma acuminata. Cancer, 88(7), 1679-1686. https://doi.org/10.1002/(SICI)1097-0142(20000401)88:7<1679::AID-CNCR23>3.0.CO;2-K

Squamous papilloma of the urinary tract is unrelated to condyloma acuminata. / Cheng, Liang; Leibovich, Bradley C.; Cheville, John C.; Ramnani, Dharamdas M.; Sebo, Thomas J.; Nehra, Ajay; Malek, Reza S.; Zincke, Horst; Bostwick, David G.

In: Cancer, Vol. 88, No. 7, 01.04.2000, p. 1679-1686.

Research output: Contribution to journalArticle

Cheng, L, Leibovich, BC, Cheville, JC, Ramnani, DM, Sebo, TJ, Nehra, A, Malek, RS, Zincke, H & Bostwick, DG 2000, 'Squamous papilloma of the urinary tract is unrelated to condyloma acuminata', Cancer, vol. 88, no. 7, pp. 1679-1686. https://doi.org/10.1002/(SICI)1097-0142(20000401)88:7<1679::AID-CNCR23>3.0.CO;2-K
Cheng, Liang ; Leibovich, Bradley C. ; Cheville, John C. ; Ramnani, Dharamdas M. ; Sebo, Thomas J. ; Nehra, Ajay ; Malek, Reza S. ; Zincke, Horst ; Bostwick, David G. / Squamous papilloma of the urinary tract is unrelated to condyloma acuminata. In: Cancer. 2000 ; Vol. 88, No. 7. pp. 1679-1686.
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abstract = "BACKGROUND. To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma. METHODS. The authors evaluated the clinical and pathologic features of squamous papilloma (5 of the bladder, 2 of the urethra), condyloma acuminatum (3 cases), and verrucous carcinoma (3 cases) of the urinary bladder and performed human papillomavirus (HPV) DNA in situ hybridization studies to determine whether HPV was a common feature shared by these lesions. In addition, DNA ploidy evaluation by image cytometry and p53 immunohistochemical staining were performed. RESULTS. Squamous papilloma of the urinary tract occurred in elderly women and followed a benign clinical course with infrequent recurrence. All squamous papillomas were HPV DNA negative and DNA diploid with no or minimal p53 nuclear accumulation. Condyloma acuminata of the bladder contained HPV DNA, increased p53 protein expression, and aneuploid DNA content. All three cases of condyloma acuminata were associated with coexistent condylomata of the external genitalia, and two required pelvic exenteration for uncontrolled expansile growth. Verrucous carcinoma of the bladder occurred in elderly patients. All three cases of verrucous carcinoma were negative for HPV DNA and DNA aneuploid, and they exhibited consistent p53 expression. CONCLUSIONS. These data indicate that squamous papilloma is a distinct entity not related to condyloma or verrucous carcinoma. These lesions are benign, HPV DNA negative, DNA diploid, and they lack p53 overaccumulation. (C) 2000 American Cancer Society.",
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AU - Cheng, Liang

AU - Leibovich, Bradley C.

AU - Cheville, John C.

AU - Ramnani, Dharamdas M.

AU - Sebo, Thomas J.

AU - Nehra, Ajay

AU - Malek, Reza S.

AU - Zincke, Horst

AU - Bostwick, David G.

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Y1 - 2000/4/1

N2 - BACKGROUND. To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma. METHODS. The authors evaluated the clinical and pathologic features of squamous papilloma (5 of the bladder, 2 of the urethra), condyloma acuminatum (3 cases), and verrucous carcinoma (3 cases) of the urinary bladder and performed human papillomavirus (HPV) DNA in situ hybridization studies to determine whether HPV was a common feature shared by these lesions. In addition, DNA ploidy evaluation by image cytometry and p53 immunohistochemical staining were performed. RESULTS. Squamous papilloma of the urinary tract occurred in elderly women and followed a benign clinical course with infrequent recurrence. All squamous papillomas were HPV DNA negative and DNA diploid with no or minimal p53 nuclear accumulation. Condyloma acuminata of the bladder contained HPV DNA, increased p53 protein expression, and aneuploid DNA content. All three cases of condyloma acuminata were associated with coexistent condylomata of the external genitalia, and two required pelvic exenteration for uncontrolled expansile growth. Verrucous carcinoma of the bladder occurred in elderly patients. All three cases of verrucous carcinoma were negative for HPV DNA and DNA aneuploid, and they exhibited consistent p53 expression. CONCLUSIONS. These data indicate that squamous papilloma is a distinct entity not related to condyloma or verrucous carcinoma. These lesions are benign, HPV DNA negative, DNA diploid, and they lack p53 overaccumulation. (C) 2000 American Cancer Society.

AB - BACKGROUND. To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma. METHODS. The authors evaluated the clinical and pathologic features of squamous papilloma (5 of the bladder, 2 of the urethra), condyloma acuminatum (3 cases), and verrucous carcinoma (3 cases) of the urinary bladder and performed human papillomavirus (HPV) DNA in situ hybridization studies to determine whether HPV was a common feature shared by these lesions. In addition, DNA ploidy evaluation by image cytometry and p53 immunohistochemical staining were performed. RESULTS. Squamous papilloma of the urinary tract occurred in elderly women and followed a benign clinical course with infrequent recurrence. All squamous papillomas were HPV DNA negative and DNA diploid with no or minimal p53 nuclear accumulation. Condyloma acuminata of the bladder contained HPV DNA, increased p53 protein expression, and aneuploid DNA content. All three cases of condyloma acuminata were associated with coexistent condylomata of the external genitalia, and two required pelvic exenteration for uncontrolled expansile growth. Verrucous carcinoma of the bladder occurred in elderly patients. All three cases of verrucous carcinoma were negative for HPV DNA and DNA aneuploid, and they exhibited consistent p53 expression. CONCLUSIONS. These data indicate that squamous papilloma is a distinct entity not related to condyloma or verrucous carcinoma. These lesions are benign, HPV DNA negative, DNA diploid, and they lack p53 overaccumulation. (C) 2000 American Cancer Society.

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KW - Condylomata acuminata

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KW - Human papillomavirus

KW - Koilocyte

KW - Neoplasms

KW - p53

KW - Papilloma

KW - Precursor

KW - Squamous lesion

KW - Verrucous carcinoma

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