Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya

Ann M. Moormann, Peter Odada Sumba, Daniel J. Tisch, Paula Embury, Charles H. King, James W. Kazura, Chandy C. John

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Long-term planning to prevent malaria epidemics requires in-depth understanding of immunity to Plasmodium falciparum in areas of unstable transmission. Cytokine responses to immunodominant epitope peptides from liver stage antigen 1 (LSA-1) and thrombospondin-related adhesive protein (TRAP) were evaluated over a nine-month interval in adults and children in Kenya from a malaria epidemic-prone highland area after several years of low transmission. The proportion and magnitude of interferon-gamma ELISPOT responses and the proportion of interleukin-10 responders to LSA-1 and TRAP peptides tended to be higher in adults than children. Frequencies of interferon-gamma responders to these peptides were similar at the two time points, but responses were not consistently generated by the same persons. These results suggest that T cell memory to prc-erythrocytic stage malaria antigens is maintained but may be unavailable for consistent detection in peripheral blood, and that these antigens induce both pro-inflammatory and anti-inflammatory cytokine responses in this population.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume81
Issue number3
DOIs
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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