Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy

Kenneth I. Wishnow, Alberto J. Ayala, A. Keith Levinson, Christopher J. Logothetis, Douglas E. Johnson, David A. Swanson, Denise M. Tenney, R. Joseph Babaian, David Grignon, Andrew C. von Eschenbach, Jae Y. Ro

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Seventy-one patients with pathologic Stage B ( P 2 3a N0) transitional cell carcinoma (TCC) of the bladder underwent radical cystectomy alone without preoperative radiotherapy or perioperative chemotherapy between 1983 and 1987 and have been followed a median of fifty months. The five-year actuarial survival and disease free survival rates were 82 percent and 77 percent, respectively, and only 13 patients (18%) have relapsed. Histologic parameters were evaluated as to prognostic impact; none correlated with disease-free survival rates although the presence of vessel involvement portended a worse disease free survival rate (68% versus 80%). During this same period, an additional 15 patients underwent radical cystectomy for pathologic Stage B disease but received adjuvant chemotherapy on the basis of vessel invasion. Their disease free survival rate at five years was 80 percent, comparable to the disease free survival rate for patients with vessel invasion treated by surgery alone (68%). Although the role of systemic chemotherapy in the management of invasive bladder cancer remains under investigation, it would appear that patients with Stage B TCC are best treated with radical cystectomy alone. Continued analysis of modern surgical results grouped by current pathologic staging criteria is needed to identify patients who have a relatively low risk of relapse and thus little need for additional therapeutic intervention. These results demonstrate that Stage P 2 3a N0 TCC of the bladder is highly curable by surgery.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalUrology
Volume39
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Transitional Cell Carcinoma
Cystectomy
Urinary Bladder
Disease-Free Survival
Survival Rate
Drug Therapy
Adjuvant Chemotherapy
Urinary Bladder Neoplasms
Radiotherapy
Recurrence
Survival

ASJC Scopus subject areas

  • Urology

Cite this

Wishnow, K. I., Ayala, A. J., Keith Levinson, A., Logothetis, C. J., Johnson, D. E., Swanson, D. A., ... Ro, J. Y. (1992). Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy. Urology, 39(1), 12-16. https://doi.org/10.1016/0090-4295(92)90033-S

Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy. / Wishnow, Kenneth I.; Ayala, Alberto J.; Keith Levinson, A.; Logothetis, Christopher J.; Johnson, Douglas E.; Swanson, David A.; Tenney, Denise M.; Joseph Babaian, R.; Grignon, David; von Eschenbach, Andrew C.; Ro, Jae Y.

In: Urology, Vol. 39, No. 1, 1992, p. 12-16.

Research output: Contribution to journalArticle

Wishnow, KI, Ayala, AJ, Keith Levinson, A, Logothetis, CJ, Johnson, DE, Swanson, DA, Tenney, DM, Joseph Babaian, R, Grignon, D, von Eschenbach, AC & Ro, JY 1992, 'Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy', Urology, vol. 39, no. 1, pp. 12-16. https://doi.org/10.1016/0090-4295(92)90033-S
Wishnow KI, Ayala AJ, Keith Levinson A, Logothetis CJ, Johnson DE, Swanson DA et al. Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy. Urology. 1992;39(1):12-16. https://doi.org/10.1016/0090-4295(92)90033-S
Wishnow, Kenneth I. ; Ayala, Alberto J. ; Keith Levinson, A. ; Logothetis, Christopher J. ; Johnson, Douglas E. ; Swanson, David A. ; Tenney, Denise M. ; Joseph Babaian, R. ; Grignon, David ; von Eschenbach, Andrew C. ; Ro, Jae Y. / Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy. In: Urology. 1992 ; Vol. 39, No. 1. pp. 12-16.
@article{1718dd450c914c0b90bd3288ebc8e16c,
title = "Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy",
abstract = "Seventy-one patients with pathologic Stage B ( P 2 3a N0) transitional cell carcinoma (TCC) of the bladder underwent radical cystectomy alone without preoperative radiotherapy or perioperative chemotherapy between 1983 and 1987 and have been followed a median of fifty months. The five-year actuarial survival and disease free survival rates were 82 percent and 77 percent, respectively, and only 13 patients (18{\%}) have relapsed. Histologic parameters were evaluated as to prognostic impact; none correlated with disease-free survival rates although the presence of vessel involvement portended a worse disease free survival rate (68{\%} versus 80{\%}). During this same period, an additional 15 patients underwent radical cystectomy for pathologic Stage B disease but received adjuvant chemotherapy on the basis of vessel invasion. Their disease free survival rate at five years was 80 percent, comparable to the disease free survival rate for patients with vessel invasion treated by surgery alone (68{\%}). Although the role of systemic chemotherapy in the management of invasive bladder cancer remains under investigation, it would appear that patients with Stage B TCC are best treated with radical cystectomy alone. Continued analysis of modern surgical results grouped by current pathologic staging criteria is needed to identify patients who have a relatively low risk of relapse and thus little need for additional therapeutic intervention. These results demonstrate that Stage P 2 3a N0 TCC of the bladder is highly curable by surgery.",
author = "Wishnow, {Kenneth I.} and Ayala, {Alberto J.} and {Keith Levinson}, A. and Logothetis, {Christopher J.} and Johnson, {Douglas E.} and Swanson, {David A.} and Tenney, {Denise M.} and {Joseph Babaian}, R. and David Grignon and {von Eschenbach}, {Andrew C.} and Ro, {Jae Y.}",
year = "1992",
doi = "10.1016/0090-4295(92)90033-S",
language = "English (US)",
volume = "39",
pages = "12--16",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Stage B ( P 2 3A N0) transitional cell carcinoma of bladder highly curable by radical cystectomy

AU - Wishnow, Kenneth I.

AU - Ayala, Alberto J.

AU - Keith Levinson, A.

AU - Logothetis, Christopher J.

AU - Johnson, Douglas E.

AU - Swanson, David A.

AU - Tenney, Denise M.

AU - Joseph Babaian, R.

AU - Grignon, David

AU - von Eschenbach, Andrew C.

AU - Ro, Jae Y.

PY - 1992

Y1 - 1992

N2 - Seventy-one patients with pathologic Stage B ( P 2 3a N0) transitional cell carcinoma (TCC) of the bladder underwent radical cystectomy alone without preoperative radiotherapy or perioperative chemotherapy between 1983 and 1987 and have been followed a median of fifty months. The five-year actuarial survival and disease free survival rates were 82 percent and 77 percent, respectively, and only 13 patients (18%) have relapsed. Histologic parameters were evaluated as to prognostic impact; none correlated with disease-free survival rates although the presence of vessel involvement portended a worse disease free survival rate (68% versus 80%). During this same period, an additional 15 patients underwent radical cystectomy for pathologic Stage B disease but received adjuvant chemotherapy on the basis of vessel invasion. Their disease free survival rate at five years was 80 percent, comparable to the disease free survival rate for patients with vessel invasion treated by surgery alone (68%). Although the role of systemic chemotherapy in the management of invasive bladder cancer remains under investigation, it would appear that patients with Stage B TCC are best treated with radical cystectomy alone. Continued analysis of modern surgical results grouped by current pathologic staging criteria is needed to identify patients who have a relatively low risk of relapse and thus little need for additional therapeutic intervention. These results demonstrate that Stage P 2 3a N0 TCC of the bladder is highly curable by surgery.

AB - Seventy-one patients with pathologic Stage B ( P 2 3a N0) transitional cell carcinoma (TCC) of the bladder underwent radical cystectomy alone without preoperative radiotherapy or perioperative chemotherapy between 1983 and 1987 and have been followed a median of fifty months. The five-year actuarial survival and disease free survival rates were 82 percent and 77 percent, respectively, and only 13 patients (18%) have relapsed. Histologic parameters were evaluated as to prognostic impact; none correlated with disease-free survival rates although the presence of vessel involvement portended a worse disease free survival rate (68% versus 80%). During this same period, an additional 15 patients underwent radical cystectomy for pathologic Stage B disease but received adjuvant chemotherapy on the basis of vessel invasion. Their disease free survival rate at five years was 80 percent, comparable to the disease free survival rate for patients with vessel invasion treated by surgery alone (68%). Although the role of systemic chemotherapy in the management of invasive bladder cancer remains under investigation, it would appear that patients with Stage B TCC are best treated with radical cystectomy alone. Continued analysis of modern surgical results grouped by current pathologic staging criteria is needed to identify patients who have a relatively low risk of relapse and thus little need for additional therapeutic intervention. These results demonstrate that Stage P 2 3a N0 TCC of the bladder is highly curable by surgery.

UR - http://www.scopus.com/inward/record.url?scp=0026610189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026610189&partnerID=8YFLogxK

U2 - 10.1016/0090-4295(92)90033-S

DO - 10.1016/0090-4295(92)90033-S

M3 - Article

C2 - 1728789

AN - SCOPUS:0026610189

VL - 39

SP - 12

EP - 16

JO - Urology

JF - Urology

SN - 0090-4295

IS - 1

ER -