Abstract
Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 112-134 |
| Number of pages | 23 |
| Journal | Histopathology |
| Volume | 74 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- metastasis
- prognosis
- staging classification
- T1 substaging
- urinary bladder
- urothelial carcinoma/neoplasia
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
Cite this
Staging of bladder cancer. / Magers, Martin J.; Lopez-Beltran, Antonio; Montironi, Rodolfo; Williamson, Sean R.; Kaimakliotis, Hristos; Cheng, Liang.
In: Histopathology, Vol. 74, No. 1, 01.01.2019, p. 112-134.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Staging of bladder cancer
AU - Magers, Martin J.
AU - Lopez-Beltran, Antonio
AU - Montironi, Rodolfo
AU - Williamson, Sean R.
AU - Kaimakliotis, Hristos
AU - Cheng, Liang
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.
AB - Urothelial carcinoma of the urinary bladder is a heterogeneous disease with multiple possible treatment modalities and a wide spectrum of clinical outcome. Treatment decisions and prognostic expectations hinge on accurate and precise staging, and the recently published American Joint Committee on Cancer (AJCC) Staging Manual, 8th edition, should be the basis for staging of urinary bladder tumours. It is unfortunate that the International Union Against Cancer (UICC) 8th edition failed to incorporate new data which is considered in the AJCC 8th edition. Thus, the AJCC 8th edition is the focus of this review. Several critical changes and clarifications are made by the AJCC 8th edition relative to the 7th edition. Although the most obvious changes in the 8th edition are in the N (i.e. perivesical lymph node involvement now classified as N1) and M (i.e. M1 is subdivided into M1a and M1b) categories, several points are clarified in the T category (e.g. substaging of pT1 should be attempted). Further optimisation, however, is required. No particular method of substaging pT1 is formally recommended. In this review, these modifications are discussed, as well as points, which require further study and optimisation.
KW - metastasis
KW - prognosis
KW - staging classification
KW - T1 substaging
KW - urinary bladder
KW - urothelial carcinoma/neoplasia
UR - http://www.scopus.com/inward/record.url?scp=85058713538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058713538&partnerID=8YFLogxK
U2 - 10.1111/his.13734
DO - 10.1111/his.13734
M3 - Review article
C2 - 30565300
AN - SCOPUS:85058713538
VL - 74
SP - 112
EP - 134
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 1
ER -