Staphylococcus aureus peptidoglycan is a toll-like receptor 2 activator: A reevaluation

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Abstract

Since the ability of peptidoglycan (PGN) to activate Toll-like receptor 2 (TLR2) was recently questioned, we reevaluated activation of TLR2 by PGN. Polymeric soluble or insoluble Staphylococcus aureus PGN, repurified by sodium dodecyl sulfate or phenol extraction, activated TLR2 at 0.1 to 1 or 10 μg/ml, respectively, and induced tumor necrosis factor alpha production. The TLR2 activation by PGN, but not by lipoteichoic acid, was abolished by muramidase digestion. We conclude that polymeric S. aureus PGN is a TLR2 activator.

Original languageEnglish
Pages (from-to)5212-5216
Number of pages5
JournalInfection and Immunity
Volume73
Issue number8
DOIs
StatePublished - Aug 2005

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Toll-Like Receptor 2
Peptidoglycan
Staphylococcus aureus
Muramidase
Phenol
Sodium Dodecyl Sulfate
Digestion
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Immunology

Cite this

Staphylococcus aureus peptidoglycan is a toll-like receptor 2 activator : A reevaluation. / Dziarski, Roman; Gupta, Dipika.

In: Infection and Immunity, Vol. 73, No. 8, 08.2005, p. 5212-5216.

Research output: Contribution to journalArticle

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