STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

Mark H. Kaplan, Nicole L. Glosson, Gretta L. Stritesky, Norman Yeh, John Kinzfogl, Sara L. Rohrabaugh, Ritobrata Goswami, Duy Pham, David E. Levy, Randy R. Brutkiewicz, Janice S. Blum, Scott Cooper, Giao Hangoc, Hal E. Broxmeyer

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25 Scopus citations

Abstract

The contribution of specific cell types to the production of cytokines that regulate hematopoiesis is still not well defined. We have previously identified T cell- dependent regulation of hematopoietic progenitor cell (HPC) numbers and cycling. In this report, we demonstrated that HPC activity is decreased in mice with STAT3-deficient T cells, a phenotype that is not because of decreased expression of IL-17 or RORγt. STAT3 expression in T cells was required for IL-21 production by multiple T helper subsets, and neutralization of IL-21 resulted in decreased HPC activity identical to that in mice with STAT3-deficient T cells. Importantly, injection of IL-21 rescued HPC activity in mice with STAT3-deficient T cells. Thus, STAT3- dependent IL-21 production in T cells is required for HPC homeostasis.

Original languageEnglish (US)
Pages (from-to)6198-6201
Number of pages4
JournalBlood
Volume117
Issue number23
DOIs
StatePublished - Jun 9 2011

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Kaplan, M. H., Glosson, N. L., Stritesky, G. L., Yeh, N., Kinzfogl, J., Rohrabaugh, S. L., Goswami, R., Pham, D., Levy, D. E., Brutkiewicz, R. R., Blum, J. S., Cooper, S., Hangoc, G., & Broxmeyer, H. E. (2011). STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis. Blood, 117(23), 6198-6201. https://doi.org/10.1182/blood-2011-02-334367