STAT4: A critical regulator of inflammation in vivo

Research output: Contribution to journalReview article

125 Scopus citations

Abstract

Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the 8 yr since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model systems. Despite the extensive study and use of these mice, the exact role of STAT4 in vivo is still unclear. In this review, I focus on describing the phenotypes of STAT4-deficient immune responses to pathogens and in diseases. Comparing the effects of STAT4 deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo.

Original languageEnglish (US)
Pages (from-to)231-241
Number of pages11
JournalImmunologic Research
Volume31
Issue number3
DOIs
StatePublished - May 18 2005

Keywords

  • Disease models
  • Inflammation
  • Interferon-γ
  • Interleukin-12
  • Pathogenesis
  • Signal transducer and activator of transcription 4

ASJC Scopus subject areas

  • Immunology

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