STAT4: A critical regulator of inflammation in vivo

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the 8 yr since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model systems. Despite the extensive study and use of these mice, the exact role of STAT4 in vivo is still unclear. In this review, I focus on describing the phenotypes of STAT4-deficient immune responses to pathogens and in diseases. Comparing the effects of STAT4 deficiency among numerous model systems will further enhance the development of a systemic model of STAT4 function in vivo.

Original languageEnglish
Pages (from-to)231-241
Number of pages11
JournalImmunologic Research
Volume31
Issue number3
DOIs
StatePublished - 2005

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STAT4 Transcription Factor
Inflammation
Immune System Diseases
Phenotype

Keywords

  • Disease models
  • Inflammation
  • Interferon-γ
  • Interleukin-12
  • Pathogenesis
  • Signal transducer and activator of transcription 4

ASJC Scopus subject areas

  • Immunology

Cite this

STAT4 : A critical regulator of inflammation in vivo. / Kaplan, Mark.

In: Immunologic Research, Vol. 31, No. 3, 2005, p. 231-241.

Research output: Contribution to journalArticle

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