STAT6 and PARP family members in the development of T cell-dependent allergic inflammation

Purna Krishnamurthy, Mark H. Kaplan

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalImmune Network
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2016

Keywords

  • Allergic inflammation
  • PARP
  • STAT
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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