STAT6 and PARP family members in the development of T cell-dependent allergic inflammation

Purna Krishnamurthy, Mark Kaplan

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalImmune Network
Volume16
Issue number4
DOIs
StatePublished - 2016

Fingerprint

Cytokines
Inflammation
T-Lymphocytes
STAT6 Transcription Factor
Eosinophilic Esophagitis
Gene Expression
Interleukin-13
Food Hypersensitivity
Atopic Dermatitis
Keratinocytes
Interleukin-4
Asthma
Epithelium
Epithelial Cells
Genes

Keywords

  • Allergic inflammation
  • PARP
  • STAT
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

STAT6 and PARP family members in the development of T cell-dependent allergic inflammation. / Krishnamurthy, Purna; Kaplan, Mark.

In: Immune Network, Vol. 16, No. 4, 2016, p. 201-210.

Research output: Contribution to journalReview article

@article{1b2afba2e3d64449be837be3044b7f94,
title = "STAT6 and PARP family members in the development of T cell-dependent allergic inflammation",
abstract = "Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.",
keywords = "Allergic inflammation, PARP, STAT, T cell",
author = "Purna Krishnamurthy and Mark Kaplan",
year = "2016",
doi = "10.4110/in.2016.16.4.201",
language = "English (US)",
volume = "16",
pages = "201--210",
journal = "Immune Network",
issn = "1598-2629",
publisher = "Korean Association of Immunologists",
number = "4",

}

TY - JOUR

T1 - STAT6 and PARP family members in the development of T cell-dependent allergic inflammation

AU - Krishnamurthy, Purna

AU - Kaplan, Mark

PY - 2016

Y1 - 2016

N2 - Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

AB - Allergic inflammation requires the orchestration of altered gene expression in the target tissue and in the infiltrating immune cells. The transcription factor STAT6 is critical in activating cytokine gene expression and cytokine signaling both in the immune cells and in target tissue cells including airway epithelia, keratinocytes and esophageal epithelial cells. STAT6 is activated by the cytokines IL-4 and IL-13 to mediate the pathogenesis of allergic disorders such as asthma, atopic dermatitis, food allergy and eosinophilic esophagitis (EoE). In this review, we summarize the role of STAT6 in allergic diseases, its interaction with the co-factor PARP14 and the molecular mechanisms by which STAT6 and PARP14 regulate gene transcription.

KW - Allergic inflammation

KW - PARP

KW - STAT

KW - T cell

UR - http://www.scopus.com/inward/record.url?scp=85020085893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020085893&partnerID=8YFLogxK

U2 - 10.4110/in.2016.16.4.201

DO - 10.4110/in.2016.16.4.201

M3 - Review article

C2 - 27574499

AN - SCOPUS:85020085893

VL - 16

SP - 201

EP - 210

JO - Immune Network

JF - Immune Network

SN - 1598-2629

IS - 4

ER -