STATdb

A specialised resource for the STATome

C. Pawan K Patro, Asif M. Khan, Tin Wee Tan, Xin Yuan Fu

Research output: Contribution to journalArticle

Abstract

Signal transducers and activators of transcription (STAT) proteins are key signalling molecules in metazoans, implicated in various cellular processes. Increased research in the field has resulted in the accumulation of STAT sequence and structure data, which are scattered across various public databases, missing extensive functional annotations, and prone to effort redundancy because of the dearth of community sharing. Therefore, there is a need to integrate the existing sequence, structure and functional data into a central repository, one that is enriched with annotations and provides a platform for community contributions. Herein, we present STATdb (publicly available at http://statdb.bic.nus.edu.sg/), the first integrated resource for STAT sequences comprising 1540 records representing the known STATome, enriched with existing structural and functional information from various databases and literature and including manual annotations. STATdb provides advanced features for data visualization, analysis and prediction, and community contributions. A key feature is a meta-predictor to characterise STAT sequences based on a novel classification that integrates STAT domain architecture, lineage and function. A curation policy workflow has been devised for regulated and structured community contributions, with an update policy for the seamless integration of new data and annotations.

Original languageEnglish
Article numbere104597
JournalPLoS One
Volume9
Issue number8
DOIs
StatePublished - Aug 26 2014

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Transcription
Transducers
STAT Transcription Factors
Databases
Data visualization
prediction
Workflow
Redundancy
proteins
Molecules
Research

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Patro, C. P. K., Khan, A. M., Tan, T. W., & Fu, X. Y. (2014). STATdb: A specialised resource for the STATome. PLoS One, 9(8), [e104597]. https://doi.org/10.1371/journal.pone.0104597

STATdb : A specialised resource for the STATome. / Patro, C. Pawan K; Khan, Asif M.; Tan, Tin Wee; Fu, Xin Yuan.

In: PLoS One, Vol. 9, No. 8, e104597, 26.08.2014.

Research output: Contribution to journalArticle

Patro, CPK, Khan, AM, Tan, TW & Fu, XY 2014, 'STATdb: A specialised resource for the STATome', PLoS One, vol. 9, no. 8, e104597. https://doi.org/10.1371/journal.pone.0104597
Patro CPK, Khan AM, Tan TW, Fu XY. STATdb: A specialised resource for the STATome. PLoS One. 2014 Aug 26;9(8). e104597. https://doi.org/10.1371/journal.pone.0104597
Patro, C. Pawan K ; Khan, Asif M. ; Tan, Tin Wee ; Fu, Xin Yuan. / STATdb : A specialised resource for the STATome. In: PLoS One. 2014 ; Vol. 9, No. 8.
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