Statin use, incident dementia and Alzheimer disease in elderly African Americans

Hugh C. Hendrie, Ann Hake, Kathleen Lane, Christianna Purnell, Frederick Unverzagt, Valerie Smith-Gamble, Jill Murrell, Adesola Ogunniyi, Olusegun Baiyewu, Chris Callahan, Andrew Saykin, Stanley Taylor, Kathleen Hall, Su Gao

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Objective: To investigate the association between statin use, incident dementia, and Alzheimer disease (AD) in a prospective elderly African American cohort. Design: Two stage design with a screening interview followed by a comprehensive in-home assessment conducted over an eight-year period. Diagnoses of incident AD and dementia were made by consensus. Statin use was collected at each evaluation. Measurements of low-density lipoprotein cholesterol (LDL), C-reactive protein (CRP) and APOE genotype were obtained from baseline blood samples. Logistic regression models were used to test the association of statin use on incident dementia and AD and its possible association with lipid and CRP levels. Setting: Indianapolis, Indiana Participants: From an original cohort of 2629 participants, a subsample of 974 African Americans aged >70 years with normal cognition, at least one follow up evaluation, complete statin information, and biomarker availability were included. Main Outcome Measures: Incident dementia and incident AD. Results: After controlling for age at diagnosis, sex, education level, presence of the APOE e4 allele and history of stroke for the incident dementia model, baseline use of statins was associated with a significantly decreased risk of incident dementia (OR=.44, P=.029) and incident AD (OR=.40, P=.029). The significant effect of statin use on reduced AD risk and trend for dementia risk was found only for those participants who reported consistent use over the observational period (incident AD: P=.034; incident dementia: P=.061). Additional models found no significant interaction between baseline statin use, baseline LDL, or CRP level and incident dementia/AD. Conclusions: Consistent use of statin medications during eight years of followup resulted in significantly reduced risk for incident AD and a trend toward reduced risk for incident dementia.

Original languageEnglish (US)
Pages (from-to)345-354
Number of pages10
JournalEthnicity and Disease
Volume25
Issue number3
DOIs
StatePublished - Jun 1 2015

Keywords

  • African Americans
  • Alzheimer disease
  • Cohort studies
  • Dementia
  • Hydroxymethylglutaryl-CoA reductase inhibitors

ASJC Scopus subject areas

  • Epidemiology

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