Steady state responses: Electrophysiological assessment of sensory function in schizophrenia

Colleen A. Brenner, Giri P. Krishnan, Jenifer L. Vohs, Woo Young Ahn, William P. Hetrick, Sandra L. Morzorati, Brian F. O'Donnell

Research output: Contribution to journalReview article

138 Scopus citations


Persons with schizophrenia experience subjective sensory anomalies and objective deficits on assessment of sensory function. Such deficits could be produced by abnormal signaling in the sensory pathways and sensory cortex or later stage disturbances in cognitive processing of such inputs. Steady state responses (SSRs) provide a noninvasive method to test the integrity of sensory pathways and oscillatory responses in schizophrenia with minimal task demands. SSRs are electrophysiological responses entrained to the frequency and phase of a periodic stimulus. Patients with schizophrenia exhibit pronounced auditory SSR deficits within the gamma frequency range (35-50 Hz) in response to click trains and amplitude-modulated tones. Visual SSR deficits are also observed, most prominently in the alpha and beta frequency ranges (7-30 Hz) in response to high-contrast, high-luminance stimuli. Visual SSR studies that have used the psychophysical properties of a stimulus to target specific visual pathways predominantly report magnocellular-based deficits in those with schizophrenia. Disruption of both auditory and visual SSRs in schizophrenia are consistent with neuropathological and magnetic resonance imaging evidence of anatomic abnormalities affecting the auditory and visual cortices. Computational models suggest that auditory SSR abnormalities at gamma frequencies could be secondary to γ-aminobutyric acid-mediated or N-methyl-D-aspartic acid dysregulation. The pathophysiological process in schizophrenia encompasses sensory processing that probably contributes to alterations in subsequent encoding and cognitive processing. The developmental evolution of these abnormalities remains to be characterized.

Original languageEnglish (US)
Pages (from-to)1065-1077
Number of pages13
JournalSchizophrenia bulletin
Issue number6
StatePublished - Nov 2009


  • EEG
  • entrainment
  • neural synchrony
  • schizophrenia
  • steady state

ASJC Scopus subject areas

  • Psychiatry and Mental health

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