Stem cell biology and its therapeutic applications in the setting of spinal cord injury

Nicholas C. Bambakidis, John Butler, Eric Horn, Xukui Wang, Mark C. Preul, Nicholas Theodore, Robert F. Spetzler, Volker K H Sonntag

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The development of an acute traumatic spinal cord injury (SCI) inevitably leads to a complex cascade of ischemia and inflammation that results in significant scar tissue formation. The development of such scar tissue provides a severe impediment to neural regeneration and healing with restoration of function. A multimodal approach to treatment is required because SCIs occur with differing levels of severity and over different lengths of time. To achieve significant breakthroughs in outcomes, such approaches must combine both neuroprotective and neuroregenerative treatments. Novel techniques modulating endogenous stem cells demonstrate great promise in promoting neuroregeneration and restoring function.

Original languageEnglish
Article numberE19
JournalNeurosurgical Focus
Volume24
Issue number3-4
DOIs
StatePublished - Mar 2008

Fingerprint

Spinal Cord Injuries
Cicatrix
Cell Biology
Stem Cells
Regeneration
Ischemia
Inflammation
Therapeutics

Keywords

  • Neuroregeneration
  • Spinal cord injury
  • Stem cell

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Bambakidis, N. C., Butler, J., Horn, E., Wang, X., Preul, M. C., Theodore, N., ... Sonntag, V. K. H. (2008). Stem cell biology and its therapeutic applications in the setting of spinal cord injury. Neurosurgical Focus, 24(3-4), [E19]. https://doi.org/10.3171/FOC/2008/24/3-4/E18

Stem cell biology and its therapeutic applications in the setting of spinal cord injury. / Bambakidis, Nicholas C.; Butler, John; Horn, Eric; Wang, Xukui; Preul, Mark C.; Theodore, Nicholas; Spetzler, Robert F.; Sonntag, Volker K H.

In: Neurosurgical Focus, Vol. 24, No. 3-4, E19, 03.2008.

Research output: Contribution to journalArticle

Bambakidis, NC, Butler, J, Horn, E, Wang, X, Preul, MC, Theodore, N, Spetzler, RF & Sonntag, VKH 2008, 'Stem cell biology and its therapeutic applications in the setting of spinal cord injury', Neurosurgical Focus, vol. 24, no. 3-4, E19. https://doi.org/10.3171/FOC/2008/24/3-4/E18
Bambakidis, Nicholas C. ; Butler, John ; Horn, Eric ; Wang, Xukui ; Preul, Mark C. ; Theodore, Nicholas ; Spetzler, Robert F. ; Sonntag, Volker K H. / Stem cell biology and its therapeutic applications in the setting of spinal cord injury. In: Neurosurgical Focus. 2008 ; Vol. 24, No. 3-4.
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