Stem cell differentiation: Cardiac repair

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Cellular transplantation has been employed for several years to deliver donor cardiomyocytes to normal and injured hearts. Recent reports of a variety of stem cells with apparent cardiomyogenic potential have raised the possibility of cell transplantation-based therapeutic interventions for heart disease. Here we review the preclinical studies demonstrating that intracardiac transplantation of skeletal myoblasts, cardiomyocytes and cardiomyogenic stem cells is feasible. In addition, recent clinical studies of skeletal myoblast and adult stem cell transplantation for heart disease are discussed.

Original languageEnglish (US)
Pages (from-to)202-211
Number of pages10
JournalCells Tissues Organs
Volume188
Issue number1-2
DOIs
StatePublished - Jul 1 2008

Keywords

  • Cardiac regeneration
  • Cell transplantation
  • Clinical studies
  • Heart disease

ASJC Scopus subject areas

  • Anatomy

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