Stem cell mechanisms and paracrine effects: Potential in cardiac surgery

Paul R. Crisostomo, Meijing Wang, Troy A. Markel, Tim Lahm, Aaron M. Abarbanell, Jeremy L. Herrmann, Daniel R. Meldrum

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.

Original languageEnglish
Pages (from-to)375-383
Number of pages9
JournalShock
Volume28
Issue number4
DOIs
StatePublished - Oct 2007

Fingerprint

Thoracic Surgery
Stem Cells
Heart Diseases
Cytoprotection
Cell- and Tissue-Based Therapy
Cause of Death
History
Therapeutics

Keywords

  • Cardioprotection
  • HGF
  • Mesenchymal
  • MSC
  • Signaling
  • VEGF

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Crisostomo, P. R., Wang, M., Markel, T. A., Lahm, T., Abarbanell, A. M., Herrmann, J. L., & Meldrum, D. R. (2007). Stem cell mechanisms and paracrine effects: Potential in cardiac surgery. Shock, 28(4), 375-383. https://doi.org/10.1097/shk.0b013e318058a817

Stem cell mechanisms and paracrine effects : Potential in cardiac surgery. / Crisostomo, Paul R.; Wang, Meijing; Markel, Troy A.; Lahm, Tim; Abarbanell, Aaron M.; Herrmann, Jeremy L.; Meldrum, Daniel R.

In: Shock, Vol. 28, No. 4, 10.2007, p. 375-383.

Research output: Contribution to journalArticle

Crisostomo, PR, Wang, M, Markel, TA, Lahm, T, Abarbanell, AM, Herrmann, JL & Meldrum, DR 2007, 'Stem cell mechanisms and paracrine effects: Potential in cardiac surgery', Shock, vol. 28, no. 4, pp. 375-383. https://doi.org/10.1097/shk.0b013e318058a817
Crisostomo, Paul R. ; Wang, Meijing ; Markel, Troy A. ; Lahm, Tim ; Abarbanell, Aaron M. ; Herrmann, Jeremy L. ; Meldrum, Daniel R. / Stem cell mechanisms and paracrine effects : Potential in cardiac surgery. In: Shock. 2007 ; Vol. 28, No. 4. pp. 375-383.
@article{1e0836adb8394d59a5e57813a8b41601,
title = "Stem cell mechanisms and paracrine effects: Potential in cardiac surgery",
abstract = "Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.",
keywords = "Cardioprotection, HGF, Mesenchymal, MSC, Signaling, VEGF",
author = "Crisostomo, {Paul R.} and Meijing Wang and Markel, {Troy A.} and Tim Lahm and Abarbanell, {Aaron M.} and Herrmann, {Jeremy L.} and Meldrum, {Daniel R.}",
year = "2007",
month = "10",
doi = "10.1097/shk.0b013e318058a817",
language = "English",
volume = "28",
pages = "375--383",
journal = "Shock",
issn = "1073-2322",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Stem cell mechanisms and paracrine effects

T2 - Potential in cardiac surgery

AU - Crisostomo, Paul R.

AU - Wang, Meijing

AU - Markel, Troy A.

AU - Lahm, Tim

AU - Abarbanell, Aaron M.

AU - Herrmann, Jeremy L.

AU - Meldrum, Daniel R.

PY - 2007/10

Y1 - 2007/10

N2 - Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.

AB - Heart disease remains the leading cause of death in the industrialized world. Stem cell therapy is a promising treatment modality for injured cardiac tissue. A novel mechanism for this cardioprotection may include paracrine actions. Cardiac surgery represents the unique situation where preischemia and postischemia treatment modalities exist that may use stem cell paracrine protection. This review (1) recalls the history of stem cells in cardiac disease and the unraveling of its mechanistic basis for protection, (2) outlines the pathways for stem cell-mediated paracrine protection, (3) highlights the signaling factors expressed, (4) explores the potential of using stem cells clinically in cardiac surgery, and (5) summarizes all human stem cell studies in cardiac disease to date.

KW - Cardioprotection

KW - HGF

KW - Mesenchymal

KW - MSC

KW - Signaling

KW - VEGF

UR - http://www.scopus.com/inward/record.url?scp=34548675564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548675564&partnerID=8YFLogxK

U2 - 10.1097/shk.0b013e318058a817

DO - 10.1097/shk.0b013e318058a817

M3 - Article

C2 - 17577135

AN - SCOPUS:34548675564

VL - 28

SP - 375

EP - 383

JO - Shock

JF - Shock

SN - 1073-2322

IS - 4

ER -