Stem cell mobilization utilizing granulocyte colony stimulating factor in advanced chronic heart failure

Lessons from a pilot study

Jacob Joseph, Paulette Mehta, Asem Rimawi, Michele Cottler-Fox, Anjan Sinha, Balkrishna Mansingh, Eugene S. Smith, Jawahar L. Mehta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mobilizing haematopoietic progenitor cells (HPC) to repair the failing heart is a promising intervention to halt the progression of this deadly disease. We postulated that low doses of granulocyte colony stimulating factor (GCSF) could successfully mobilize HPC in advanced systolic heart failure and lead to beneficial effects. In a pilot study involving patients with advanced systolic heart failure, we established that a low dose (5 μg/kg/day for 5 days) of GCSF was sufficient to mobilize HPC into the peripheral blood in adequate numbers (>10 cells/μL) in spite of advanced heart failure and subject age. A striking observation was the significant elevation of plasma interleukin-10 levels in response to GCSF, without any change in tumour necrosis factor-α or interferon-γ levels. Left ventricular function improved significantly in subjects with ischaemic cardiomyopathy at 9 months after a single 5-day cycle of GCSF. Our results suggest the potential for improving left ventricular function in advanced systolic heart failure utilizing GCSF.

Original languageEnglish (US)
JournalEuropean Heart Journal, Supplement
Volume10
Issue numberK
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Mobilization
Granulocyte Colony-Stimulating Factor
Systolic Heart Failure
Heart Failure
Hematopoietic Stem Cells
Left Ventricular Function
Cardiomyopathies
Interleukin-10
Interferons
Disease Progression
Tumor Necrosis Factor-alpha
Observation

Keywords

  • Cytokines
  • Heart failure
  • Stem cells
  • Ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Stem cell mobilization utilizing granulocyte colony stimulating factor in advanced chronic heart failure : Lessons from a pilot study. / Joseph, Jacob; Mehta, Paulette; Rimawi, Asem; Cottler-Fox, Michele; Sinha, Anjan; Mansingh, Balkrishna; Smith, Eugene S.; Mehta, Jawahar L.

In: European Heart Journal, Supplement, Vol. 10, No. K, 2008.

Research output: Contribution to journalArticle

Joseph, Jacob ; Mehta, Paulette ; Rimawi, Asem ; Cottler-Fox, Michele ; Sinha, Anjan ; Mansingh, Balkrishna ; Smith, Eugene S. ; Mehta, Jawahar L. / Stem cell mobilization utilizing granulocyte colony stimulating factor in advanced chronic heart failure : Lessons from a pilot study. In: European Heart Journal, Supplement. 2008 ; Vol. 10, No. K.
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