Stem cell therapy for ischemic heart disease

Rutger J. Hassink, Joshua D. Dowell, Aart Brutel De la Rivière, Pieter A. Doevendans, Loren Field

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Recent experimental and clinical observations have suggested that cell transplantation could be of therapeutic value for the treatment of heart disease. This approach was based on the idea that transplanted donor cardiomyocytes would integrate with the host myocardium and thereby directly contribute to cardiac function. Surprisingly, the observation that non-cardiomyogenic cells could also improve cardiac function indicates that functional integration of donor cells might not be required to achieve a beneficial effect. More recently, several observations have suggested the presence of a greater than anticipated developmental repertoire in adult-derived stem cells, which, if further validated, would offer unprecedented opportunities for the restoration of cardiac function in diseased hearts. Here, we discuss current issues regarding the potential use of stem cell transplantation for the treatment of ischemic heart disease.

Original languageEnglish
Pages (from-to)436-441
Number of pages6
JournalTrends in Molecular Medicine
Volume9
Issue number10
DOIs
StatePublished - Oct 2003

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Cell- and Tissue-Based Therapy
Myocardial Ischemia
Stem Cells
Heart Diseases
Adult Stem Cells
Cell Transplantation
Stem Cell Transplantation
Cardiac Myocytes
Myocardium
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hassink, R. J., Dowell, J. D., De la Rivière, A. B., Doevendans, P. A., & Field, L. (2003). Stem cell therapy for ischemic heart disease. Trends in Molecular Medicine, 9(10), 436-441. https://doi.org/10.1016/j.molmed.2003.08.002

Stem cell therapy for ischemic heart disease. / Hassink, Rutger J.; Dowell, Joshua D.; De la Rivière, Aart Brutel; Doevendans, Pieter A.; Field, Loren.

In: Trends in Molecular Medicine, Vol. 9, No. 10, 10.2003, p. 436-441.

Research output: Contribution to journalArticle

Hassink, RJ, Dowell, JD, De la Rivière, AB, Doevendans, PA & Field, L 2003, 'Stem cell therapy for ischemic heart disease', Trends in Molecular Medicine, vol. 9, no. 10, pp. 436-441. https://doi.org/10.1016/j.molmed.2003.08.002
Hassink RJ, Dowell JD, De la Rivière AB, Doevendans PA, Field L. Stem cell therapy for ischemic heart disease. Trends in Molecular Medicine. 2003 Oct;9(10):436-441. https://doi.org/10.1016/j.molmed.2003.08.002
Hassink, Rutger J. ; Dowell, Joshua D. ; De la Rivière, Aart Brutel ; Doevendans, Pieter A. ; Field, Loren. / Stem cell therapy for ischemic heart disease. In: Trends in Molecular Medicine. 2003 ; Vol. 9, No. 10. pp. 436-441.
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