Stem cell therapy for ischemic heart disease

Rutger J. Hassink, Joshua D. Dowell, Aart Brutel De la Rivière, Pieter A. Doevendans, Loren J. Field

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Recent experimental and clinical observations have suggested that cell transplantation could be of therapeutic value for the treatment of heart disease. This approach was based on the idea that transplanted donor cardiomyocytes would integrate with the host myocardium and thereby directly contribute to cardiac function. Surprisingly, the observation that non-cardiomyogenic cells could also improve cardiac function indicates that functional integration of donor cells might not be required to achieve a beneficial effect. More recently, several observations have suggested the presence of a greater than anticipated developmental repertoire in adult-derived stem cells, which, if further validated, would offer unprecedented opportunities for the restoration of cardiac function in diseased hearts. Here, we discuss current issues regarding the potential use of stem cell transplantation for the treatment of ischemic heart disease.

Original languageEnglish (US)
Pages (from-to)436-441
Number of pages6
JournalTrends in Molecular Medicine
Volume9
Issue number10
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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    Hassink, R. J., Dowell, J. D., De la Rivière, A. B., Doevendans, P. A., & Field, L. J. (2003). Stem cell therapy for ischemic heart disease. Trends in Molecular Medicine, 9(10), 436-441. https://doi.org/10.1016/j.molmed.2003.08.002