Stem cell transplantation as a therapeutic approach to organ failure

Ryan D. Nagy, Ben M. Tsai, Meijing Wang, Troy A. Markel, John Brown, Daniel R. Meldrum

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background. Stem cell transplantation is one of the next great frontiers for surgery. Stem cells, which are undifferentiated and self-renewing, have shown the ability to differentiate into cardiomyocytes, as well as many other cell types for potential therapeutic use by surgeons. Materials and methods. As a result, stem cells have the potential to undo irreversible cellular damage, something traditional therapies could not cure. However, numerous issues must be resolved to permit safe and effective clinical application of stem cell therapy. These include the interpretation of cellular labeling, the origin of replicating myocytes, the homing mechanism of stem cells, and the differentiation process. Results. Successful translational research will depend on precise delivery of these cells in real time to the area of interest, e.g., the spinal cord, liver, or heart. Surgeons will be better able to excise and replace/regrow, rather than excise alone. As such, a basic understanding of stem cell biology will benefit the surgeon scientist and clinical surgeon. Conclusions. The review: 1) discusses myocardial regeneration; 2) defines and categorizes stem cells; 3) presents evidence of stem cell transdifferentiation into cardiomyocytes; and, 4) delineates the therapeutic potential of stem cells in the treatment of ischemic heart disease.

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalJournal of Surgical Research
Volume129
Issue number1
DOIs
StatePublished - Nov 2005

Fingerprint

Stem Cell Transplantation
Stem Cells
Therapeutics
Cardiac Myocytes
Cell Transdifferentiation
Translational Medical Research
Therapeutic Uses
Cell- and Tissue-Based Therapy
Muscle Cells
Myocardial Ischemia
Cell Biology
Regeneration
Cell Differentiation
Spinal Cord
Surgeons
Liver

Keywords

  • Cell-based therapy
  • Cellular differentiation
  • Myocardial regeneration
  • Progenitor cells
  • Stem cells

ASJC Scopus subject areas

  • Surgery

Cite this

Stem cell transplantation as a therapeutic approach to organ failure. / Nagy, Ryan D.; Tsai, Ben M.; Wang, Meijing; Markel, Troy A.; Brown, John; Meldrum, Daniel R.

In: Journal of Surgical Research, Vol. 129, No. 1, 11.2005, p. 152-160.

Research output: Contribution to journalArticle

Nagy, Ryan D. ; Tsai, Ben M. ; Wang, Meijing ; Markel, Troy A. ; Brown, John ; Meldrum, Daniel R. / Stem cell transplantation as a therapeutic approach to organ failure. In: Journal of Surgical Research. 2005 ; Vol. 129, No. 1. pp. 152-160.
@article{e1e05cc36f0d4525b484ad5b79340bd8,
title = "Stem cell transplantation as a therapeutic approach to organ failure",
abstract = "Background. Stem cell transplantation is one of the next great frontiers for surgery. Stem cells, which are undifferentiated and self-renewing, have shown the ability to differentiate into cardiomyocytes, as well as many other cell types for potential therapeutic use by surgeons. Materials and methods. As a result, stem cells have the potential to undo irreversible cellular damage, something traditional therapies could not cure. However, numerous issues must be resolved to permit safe and effective clinical application of stem cell therapy. These include the interpretation of cellular labeling, the origin of replicating myocytes, the homing mechanism of stem cells, and the differentiation process. Results. Successful translational research will depend on precise delivery of these cells in real time to the area of interest, e.g., the spinal cord, liver, or heart. Surgeons will be better able to excise and replace/regrow, rather than excise alone. As such, a basic understanding of stem cell biology will benefit the surgeon scientist and clinical surgeon. Conclusions. The review: 1) discusses myocardial regeneration; 2) defines and categorizes stem cells; 3) presents evidence of stem cell transdifferentiation into cardiomyocytes; and, 4) delineates the therapeutic potential of stem cells in the treatment of ischemic heart disease.",
keywords = "Cell-based therapy, Cellular differentiation, Myocardial regeneration, Progenitor cells, Stem cells",
author = "Nagy, {Ryan D.} and Tsai, {Ben M.} and Meijing Wang and Markel, {Troy A.} and John Brown and Meldrum, {Daniel R.}",
year = "2005",
month = "11",
doi = "10.1016/j.jss.2005.04.016",
language = "English",
volume = "129",
pages = "152--160",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Stem cell transplantation as a therapeutic approach to organ failure

AU - Nagy, Ryan D.

AU - Tsai, Ben M.

AU - Wang, Meijing

AU - Markel, Troy A.

AU - Brown, John

AU - Meldrum, Daniel R.

PY - 2005/11

Y1 - 2005/11

N2 - Background. Stem cell transplantation is one of the next great frontiers for surgery. Stem cells, which are undifferentiated and self-renewing, have shown the ability to differentiate into cardiomyocytes, as well as many other cell types for potential therapeutic use by surgeons. Materials and methods. As a result, stem cells have the potential to undo irreversible cellular damage, something traditional therapies could not cure. However, numerous issues must be resolved to permit safe and effective clinical application of stem cell therapy. These include the interpretation of cellular labeling, the origin of replicating myocytes, the homing mechanism of stem cells, and the differentiation process. Results. Successful translational research will depend on precise delivery of these cells in real time to the area of interest, e.g., the spinal cord, liver, or heart. Surgeons will be better able to excise and replace/regrow, rather than excise alone. As such, a basic understanding of stem cell biology will benefit the surgeon scientist and clinical surgeon. Conclusions. The review: 1) discusses myocardial regeneration; 2) defines and categorizes stem cells; 3) presents evidence of stem cell transdifferentiation into cardiomyocytes; and, 4) delineates the therapeutic potential of stem cells in the treatment of ischemic heart disease.

AB - Background. Stem cell transplantation is one of the next great frontiers for surgery. Stem cells, which are undifferentiated and self-renewing, have shown the ability to differentiate into cardiomyocytes, as well as many other cell types for potential therapeutic use by surgeons. Materials and methods. As a result, stem cells have the potential to undo irreversible cellular damage, something traditional therapies could not cure. However, numerous issues must be resolved to permit safe and effective clinical application of stem cell therapy. These include the interpretation of cellular labeling, the origin of replicating myocytes, the homing mechanism of stem cells, and the differentiation process. Results. Successful translational research will depend on precise delivery of these cells in real time to the area of interest, e.g., the spinal cord, liver, or heart. Surgeons will be better able to excise and replace/regrow, rather than excise alone. As such, a basic understanding of stem cell biology will benefit the surgeon scientist and clinical surgeon. Conclusions. The review: 1) discusses myocardial regeneration; 2) defines and categorizes stem cells; 3) presents evidence of stem cell transdifferentiation into cardiomyocytes; and, 4) delineates the therapeutic potential of stem cells in the treatment of ischemic heart disease.

KW - Cell-based therapy

KW - Cellular differentiation

KW - Myocardial regeneration

KW - Progenitor cells

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=27144507831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27144507831&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2005.04.016

DO - 10.1016/j.jss.2005.04.016

M3 - Article

C2 - 16045936

AN - SCOPUS:27144507831

VL - 129

SP - 152

EP - 160

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 1

ER -