Stem cell use in a patient with an ischemic foot ulcer

A case study

Debra Kohlman-Trigoboff, Jeffrey H. Lawson, Michael Murphy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Stem cell research has been discussed in both the political and popular arenas lately. Some types of stem cell research are controversial; however, not all stem cell research involves harvesting cells from an embryo or an aborted fetus. Another type of stem cell, the adult stem cell, resides within tissues and organs of the body and is responsible for repair after injury. Recent interest has focused on using adult stem cells isolated from a patient's bone marrow to stimulate the development of new blood vessels (a process called angiogenesis) in patients with peripheral vascular disease. These specialized stem cells are referred to as endothelial progenitor cells (EPCs). In laboratory and clinical studies it has been shown that these EPCs are involved in arterial repair and remodeling, as well as angiogenesis. The following case presentation will show how a patient with an ischemic toe ulcer and rest pain, who had no options for conventional revascularization, benefited from the injection of stem cells into her calf muscle. The process of angiogenesis using EPCs will be examined discussing the screening criteria and possible adverse events. The patient's history and progress throughout the recovery period will be reviewed.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalJournal of Vascular Nursing
Volume24
Issue number2
DOIs
StatePublished - Jun 2006
Externally publishedYes

Fingerprint

Foot Ulcer
Stem Cell Research
Stem Cells
Adult Stem Cells
Aborted Fetus
Peripheral Vascular Diseases
Toes
Ulcer
Blood Vessels
Embryonic Structures
Bone Marrow
Pain
Muscles
Injections
Wounds and Injuries
Endothelial Progenitor Cells

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Stem cell use in a patient with an ischemic foot ulcer : A case study. / Kohlman-Trigoboff, Debra; Lawson, Jeffrey H.; Murphy, Michael.

In: Journal of Vascular Nursing, Vol. 24, No. 2, 06.2006, p. 56-61.

Research output: Contribution to journalArticle

Kohlman-Trigoboff, Debra ; Lawson, Jeffrey H. ; Murphy, Michael. / Stem cell use in a patient with an ischemic foot ulcer : A case study. In: Journal of Vascular Nursing. 2006 ; Vol. 24, No. 2. pp. 56-61.
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