Stem cells as a potential future treatment of pediatric intestinal disorders

Troy A. Markel, Paul R. Crisostomo, Tim Lahm, Nathan M. Novotny, Frederick J. Rescorla, Joseph Tector, Daniel R. Meldrum

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

All surgical disciplines encounter planned and unplanned ischemic events that may ultimately lead to cellular dysfunction and death. Stem cell therapy has shown promise for the treatment of a variety of ischemic and inflammatory disorders where tissue damage has occurred. As stem cells have proven beneficial in many disease processes, important opportunities in the future treatment of gastrointestinal disorders may exist. Therefore, this article will serve to review the different types of stem cells that may be applicable to the treatment of gastrointestinal disorders, review the mechanisms suggesting that stem cells may work for these conditions, discuss current practices for harvesting and purifying stem cells, and provide a concise summary of a few of the pediatric intestinal disorders that could be treated with cellular therapy.

Original languageEnglish (US)
Pages (from-to)1953-1963
Number of pages11
JournalJournal of pediatric surgery
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2008

Keywords

  • Gastrointestinal disorder
  • Inflammatory disorder
  • Ischemic disorder
  • Pediatric
  • Stem cell therapy

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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